1gd5: Difference between revisions

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[[Image:1gd5.jpg|left|200px]]
{{Seed}}
[[Image:1gd5.png|left|200px]]


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{{STRUCTURE_1gd5|  PDB=1gd5  |  SCENE=  }}  
{{STRUCTURE_1gd5|  PDB=1gd5  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE PX DOMAIN FROM HUMAN P47PHOX NADPH OXIDASE'''
===SOLUTION STRUCTURE OF THE PX DOMAIN FROM HUMAN P47PHOX NADPH OXIDASE===




==Overview==
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The phox homology (PX) domain is a novel protein module containing a conserved proline-rich motif. We have shown that the PX domain isolated from the human p47phox protein, a soluble subunit of phagocyte NADPH oxidase, binds specifically to the C-terminal SH3 domain derived from the same protein. The solution structure of p47 PX has an alpha + beta structure with a novel folding motif topology and reveals that the proline-rich motif is presented on the molecular surface for easy recognition by the SH3 domain. The proline-rich motif of p47 PX in the free state adopts a distorted left-handed polyproline type II helix conformation.
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{{ABSTRACT_PUBMED_11373621}}


==About this Structure==
==About this Structure==
1GD5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD5 OCA].  
1GD5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD5 OCA].  


==Reference==
==Reference==
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[[Category: Sumimoto, H.]]
[[Category: Sumimoto, H.]]
[[Category: Alpha beta,p47-phox,px domain]]
[[Category: Alpha beta,p47-phox,px domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:26:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:07:21 2008''

Revision as of 02:07, 1 July 2008

File:1gd5.png

Template:STRUCTURE 1gd5

SOLUTION STRUCTURE OF THE PX DOMAIN FROM HUMAN P47PHOX NADPH OXIDASE

Template:ABSTRACT PUBMED 11373621

About this Structure

1GD5 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the PX domain, a target of the SH3 domain., Hiroaki H, Ago T, Ito T, Sumimoto H, Kohda D, Nat Struct Biol. 2001 Jun;8(6):526-30. PMID:11373621

Page seeded by OCA on Tue Jul 1 05:07:21 2008

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