7vm9: Difference between revisions
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==Solution NMR structures of DNA minidumbbell formed with two regular CTTTG pentaloops== | ==Solution NMR structures of DNA minidumbbell formed with two regular CTTTG pentaloops== | ||
<StructureSection load='7vm9' size='340' side='right'caption='[[7vm9]]' scene=''> | <StructureSection load='7vm9' size='340' side='right'caption='[[7vm9]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full | <table><tr><td colspan='2'>[[7vm9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VM9 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vm9 OCA], [https://pdbe.org/7vm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vm9 RCSB], [https://www.ebi.ac.uk/pdbsum/7vm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vm9 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vm9 OCA], [https://pdbe.org/7vm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vm9 RCSB], [https://www.ebi.ac.uk/pdbsum/7vm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vm9 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Minidumbbell (MDB) is a noncanonical DNA structure found to form in several pyrimidine-rich short tandem repeats associated with neurodegenerative diseases. The most recently reported MDB contains two pentaloops formed by ATTCT repeats. Here, we studied the effects of a purine residue and a backbone discontinuous site on the structure and thermal stability of MDBs containing two pentaloops. It was found that a purine as the fourth loop residue improved the thermal stability of MDBs containing two regular pentaloops, while a backbone discontinuous site between the third and fourth, or between the fourth and fifth loop residues enhanced the thermal stability of MDBs containing a regular and a quasi pentaloops. The results of this study provide new insights into the sequence criteria and structural basis of MDBs. | |||
A purine and a backbone discontinuous site alter the structure and thermal stability of DNA minidumbbells containing two pentaloops.,Ngai CK, Lam SL, Lee HK, Guo P FEBS Lett. 2022 Jan 21. doi: 10.1002/1873-3468.14293. PMID:35060128<ref>PMID:35060128</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7vm9" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Guo P]] | [[Category: Guo, P]] | ||
[[Category: Ngai | [[Category: Ngai, C K]] | ||
[[Category: Ctttg pentaloop]] | |||
[[Category: Dna]] | |||
[[Category: Dna structure]] | |||
[[Category: Minidumbbell]] | |||
