2m9e: Difference between revisions

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==NMR solution structure of Pin1 WW domain mutant 5-1==
==NMR solution structure of Pin1 WW domain mutant 5-1==
<StructureSection load='2m9e' size='340' side='right'caption='[[2m9e]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2m9e' size='340' side='right'caption='[[2m9e]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2m9e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M9E FirstGlance]. <br>
<table><tr><td colspan='2'>[[2m9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M9E FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2m9f|2m9f]], [[2m9i|2m9i]], [[2m9j|2m9j]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9e OCA], [https://pdbe.org/2m9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m9e RCSB], [https://www.ebi.ac.uk/pdbsum/2m9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m9e OCA], [https://pdbe.org/2m9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m9e RCSB], [https://www.ebi.ac.uk/pdbsum/2m9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m9e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
[https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen, W]]
[[Category: Chen W]]
[[Category: Dyson, H J]]
[[Category: Dyson HJ]]
[[Category: Enck, S]]
[[Category: Enck S]]
[[Category: Kelly, J W]]
[[Category: Kelly JW]]
[[Category: Powers, E T]]
[[Category: Powers ET]]
[[Category: Price, J L]]
[[Category: Price JL]]
[[Category: Wong, C]]
[[Category: Wong C]]
[[Category: Ch-pi interaction]]
[[Category: Enhanced aromatic sequon]]
[[Category: Isomerase]]
[[Category: N-glycosylation]]
[[Category: Ww domain]]
Retrieved from "https://proteopedia.org/2m9e"