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==Solution NMR Structure of BRCT Domain of T. Thermophilus: Northeast Structural Genomics Consortium Target WR64TT==
==Solution NMR Structure of BRCT Domain of T. Thermophilus: Northeast Structural Genomics Consortium Target WR64TT==
<StructureSection load='1l7b' size='340' side='right'caption='[[1l7b]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='1l7b' size='340' side='right'caption='[[1l7b]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1l7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L7B FirstGlance]. <br>
<table><tr><td colspan='2'>[[1l7b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L7B FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DNLJ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_ligase_(NAD(+)) DNA ligase (NAD(+))], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.2 6.5.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l7b OCA], [https://pdbe.org/1l7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l7b RCSB], [https://www.ebi.ac.uk/pdbsum/1l7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l7b ProSAT], [https://www.topsan.org/Proteins/NESGC/1l7b TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l7b OCA], [https://pdbe.org/1l7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l7b RCSB], [https://www.ebi.ac.uk/pdbsum/1l7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l7b ProSAT], [https://www.topsan.org/Proteins/NESGC/1l7b TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DNLJ_THET8 DNLJ_THET8]] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.  
[https://www.uniprot.org/uniprot/DNLJ_THET8 DNLJ_THET8] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Anderson, S]]
[[Category: Thermus thermophilus]]
[[Category: Aramini, J]]
[[Category: Anderson S]]
[[Category: Bhattacharya, D]]
[[Category: Aramini J]]
[[Category: Dixon, B L]]
[[Category: Bhattacharya D]]
[[Category: Huang, Y P]]
[[Category: Dixon BL]]
[[Category: Monleon, D]]
[[Category: Huang YP]]
[[Category: Montelione, G T]]
[[Category: Monleon D]]
[[Category: Structural genomic]]
[[Category: Montelione GT]]
[[Category: Sahota, G]]
[[Category: Sahota G]]
[[Category: Swapna, G V.T]]
[[Category: Swapna GVT]]
[[Category: Tejero, R]]
[[Category: Tejero R]]
[[Category: Xiao, R]]
[[Category: Xiao R]]
[[Category: Yin, C]]
[[Category: Yin C]]
[[Category: Autostructure]]
[[Category: Brct]]
[[Category: Dna ligase]]
[[Category: Ligase]]
[[Category: Nesg]]
[[Category: PSI, Protein structure initiative]]
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