1ggi: Difference between revisions

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[[Image:1ggi.~~gif~~|left|200px]]

[[Image:1ggi.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN~~'''~~

===CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN===

~~==Overview==~~

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The ~~crystal structure of~~ the ~~Fab fragment of a human immunodeficiency virus type 1~~ (~~HIV-1) neutralizing monoclonal antibody Fab has been determined~~ at 2.~~8 A resolution in complex with a linear 16-residue peptide from the third hypervariable region (V3~~) ~~of gp120. The first 9 residues of the peptide are ordered in the electron density maps~~, ~~and their conformation~~ is ~~in partial agreement with the beta-strand-type II beta-turn structure predicted for this portion of~~ the ~~V3 loop~~. ~~Notably, several of the peptide residues that are well conserved among different HIV~~-~~1 isolates contact a nonpolar 25~~-A-long groove in the antibody-combining site. The largely extended structure of the peptide differs from the beta-turns seen as the primary determinants in other published anti-peptide Fab structures. Analysis of the specific Fab-peptide interactions only partially explains the MN isolate specificity shown by this antibody.

The line below this paragraph, {{ABSTRACT_PUBMED_8327513}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8327513 is the PubMed ID number.

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==About this Structure==

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[[Category: Wilson, I A.]]

[[Category: Immunoglobulin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 17~~:31:58 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:14:59 2008''

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-[[Image:1ggi.gif|left|200px]]
+{{Seed}}
+[[Image:1ggi.png|left|200px]]
 <!--
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 {{STRUCTURE_1ggi|  PDB=1ggi  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN'''
+===CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN===
-==Overview==
+<!--
-The crystal structure of the Fab fragment of a human immunodeficiency virus type 1 (HIV-1) neutralizing monoclonal antibody Fab has been determined at 2.8 A resolution in complex with a linear 16-residue peptide from the third hypervariable region (V3) of gp120. The first 9 residues of the peptide are ordered in the electron density maps, and their conformation is in partial agreement with the beta-strand-type II beta-turn structure predicted for this portion of the V3 loop. Notably, several of the peptide residues that are well conserved among different HIV-1 isolates contact a nonpolar 25-A-long groove in the antibody-combining site. The largely extended structure of the peptide differs from the beta-turns seen as the primary determinants in other published anti-peptide Fab structures. Analysis of the specific Fab-peptide interactions only partially explains the MN isolate specificity shown by this antibody.
+The line below this paragraph, {{ABSTRACT_PUBMED_8327513}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8327513 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8327513}}
 ==About this Structure==
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 [[Category: Wilson, I A.]]
 [[Category: Immunoglobulin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:31:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 05:14:59 2008''