1ggt: Difference between revisions

Line 1:

[[Image:1ggt.~~gif~~|left|200px]]

[[Image:1ggt.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~THREE-DIMENSIONAL STRUCTURE OF A TRANSGLUTAMINASE: HUMAN BLOOD COAGULATION FACTOR XIII~~'''~~

===THREE-DIMENSIONAL STRUCTURE OF A TRANSGLUTAMINASE: HUMAN BLOOD COAGULATION FACTOR XIII===

~~==Overview==~~

<!--

~~Mechanical stability in many biological materials is provided by the crosslinking of large structural proteins with gamma~~-~~glutamyl~~-~~epsilon-lysyl amide bonds.~~ The ~~three-dimensional structure of human recombinant factor XIII~~ (~~EC 2~~.3.~~2.13 zymogen; protein-glutamine:amine gamma-glutamyltransferase a chain~~), ~~a transglutaminase zymogen, has been solved at 2.8-A resolution by x-ray crystallography. This structure shows that each chain of the homodimeric protein~~ is ~~folded into four sequential domains. A catalytic triad reminiscent of that observed in cysteine proteases has been identified in~~ the ~~core domain~~. ~~The amino~~-terminal activation peptide of each subunit crosses the dimer interface and partially occludes the opening of the catalytic cavity in the second subunit, preventing substrate binding to the zymogen. A proposal for the mechanism of activation by thrombin and calcium is made that details the structural events leading to active factor XIIIa'.

The line below this paragraph, {{ABSTRACT_PUBMED_7913750}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 7913750 is the PubMed ID number.

-->

==About this Structure==

Line 30:

Line 34:

[[Category: Yee, V C.]]

[[Category: Blood coagulation]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 17~~:32:33 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:15:49 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1ggt.gif|left|200px]]
+{{Seed}}
+[[Image:1ggt.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1ggt|  PDB=1ggt  |  SCENE=  }}
-'''THREE-DIMENSIONAL STRUCTURE OF A TRANSGLUTAMINASE: HUMAN BLOOD COAGULATION FACTOR XIII'''
+===THREE-DIMENSIONAL STRUCTURE OF A TRANSGLUTAMINASE: HUMAN BLOOD COAGULATION FACTOR XIII===
-==Overview==
+<!--
-Mechanical stability in many biological materials is provided by the crosslinking of large structural proteins with gamma-glutamyl-epsilon-lysyl amide bonds. The three-dimensional structure of human recombinant factor XIII (EC 2.3.2.13 zymogen; protein-glutamine:amine gamma-glutamyltransferase a chain), a transglutaminase zymogen, has been solved at 2.8-A resolution by x-ray crystallography. This structure shows that each chain of the homodimeric protein is folded into four sequential domains. A catalytic triad reminiscent of that observed in cysteine proteases has been identified in the core domain. The amino-terminal activation peptide of each subunit crosses the dimer interface and partially occludes the opening of the catalytic cavity in the second subunit, preventing substrate binding to the zymogen. A proposal for the mechanism of activation by thrombin and calcium is made that details the structural events leading to active factor XIIIa'.
+The line below this paragraph, {{ABSTRACT_PUBMED_7913750}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7913750 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7913750}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Yee, V C.]]
 [[Category: Blood coagulation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:32:33 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 05:15:49 2008''