3f9v: Difference between revisions
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<StructureSection load='3f9v' size='340' side='right'caption='[[3f9v]], [[Resolution|resolution]] 4.35Å' scene=''> | <StructureSection load='3f9v' size='340' side='right'caption='[[3f9v]], [[Resolution|resolution]] 4.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3f9v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3f9v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F9V FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.35Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9v OCA], [https://pdbe.org/3f9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f9v RCSB], [https://www.ebi.ac.uk/pdbsum/3f9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9v ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9v OCA], [https://pdbe.org/3f9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f9v RCSB], [https://www.ebi.ac.uk/pdbsum/3f9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9v ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/MCM_SACS2 MCM_SACS2] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Brewster | [[Category: Saccharolobus solfataricus]] | ||
[[Category: Chen | [[Category: Brewster AS]] | ||
[[Category: Greenleaf | [[Category: Chen XJ]] | ||
[[Category: Klein | [[Category: Greenleaf W]] | ||
[[Category: Tjajadi | [[Category: Klein M]] | ||
[[Category: Wang | [[Category: Tjajadi M]] | ||
[[Category: Yu | [[Category: Wang GG]] | ||
[[Category: Yu X]] | |||
