1gik: Difference between revisions

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[[Image:1gik.gif|left|200px]]
{{Seed}}
[[Image:1gik.png|left|200px]]


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{{STRUCTURE_1gik|  PDB=1gik  |  SCENE=  }}  
{{STRUCTURE_1gik|  PDB=1gik  |  SCENE=  }}  


'''POKEWEED ANTIVIRAL PROTEIN FROM SEEDS'''
===POKEWEED ANTIVIRAL PROTEIN FROM SEEDS===




==Overview==
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The crystal structure of pokeweed antiviral protein from seeds of Phytolacca americana (PAP-S) was solved at 1.8A. PAP-S is a one-chain ribosome-inactivating protein (RIP) and distinctively contains three well-defined N-acetylglucosamines, each covalently linked to an asparagine residue at positions, 10, 44, and 255, respectively. The high-resolution structure clearly shows the three mono-sugars to have either an alpha- or a beta-conformation. Two of sugars are located on the same side of the molecule with the active pocket. Except one hydrogen bond, there are no intermolecular interactions between the polypeptide chain and the sugars. Instead the sugar conformations appear to be stabilized by intermolecular interactions. The sugar structure defined at high resolution provides a structural basis for understanding their possible biological activity. The structural comparisons of PAP-S with other PAPs reveal that the major disparity of these homologous molecules is the different charge distribution on the upper right side of the front side near the active pocket. Based on the available structure of the 50S ribosomal subunit, the possible interactions between PAPs and the ribosome are discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_12615543}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12615543 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12615543}}


==About this Structure==
==About this Structure==
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[[Category: Zeng, Z H.]]
[[Category: Zeng, Z H.]]
[[Category: Alpha+beta]]
[[Category: Alpha+beta]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:37:01 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:21:05 2008''

Revision as of 02:21, 1 July 2008

File:1gik.png

Template:STRUCTURE 1gik

POKEWEED ANTIVIRAL PROTEIN FROM SEEDS

Template:ABSTRACT PUBMED 12615543

About this Structure

1GIK is a Single protein structure of sequence from Phytolacca americana. Full crystallographic information is available from OCA.

Reference

Crystal structure of pokeweed antiviral protein with well-defined sugars from seeds at 1.8A resolution., Zeng ZH, He XL, Li HM, Hu Z, Wang DC, J Struct Biol. 2003 Feb;141(2):171-8. PMID:12615543

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