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==NMR solution structure of the putative cation transport regulator ChaB==
==NMR solution structure of the putative cation transport regulator ChaB==
<StructureSection load='1sg7' size='340' side='right'caption='[[1sg7]], [[NMR_Ensembles_of_Models | 17 NMR models]]' scene=''>
<StructureSection load='1sg7' size='340' side='right'caption='[[1sg7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1sg7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SG7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1sg7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SG7 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHAB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sg7 OCA], [https://pdbe.org/1sg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sg7 RCSB], [https://www.ebi.ac.uk/pdbsum/1sg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sg7 ProSAT], [https://www.topsan.org/Proteins/BSGI/1sg7 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sg7 OCA], [https://pdbe.org/1sg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sg7 RCSB], [https://www.ebi.ac.uk/pdbsum/1sg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sg7 ProSAT], [https://www.topsan.org/Proteins/BSGI/1sg7 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CHAB_ECO57 CHAB_ECO57] Might be a regulator of the sodium-potassium/proton antiporter ChaA.<ref>PMID:15306028</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sg7 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sg7 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
BACKGROUND: ChaB is a putative regulator of ChaA, a Na+/H+ antiporter that also has Ca+/H+ activity in E. coli. ChaB contains a conserved 60-residue region of unknown function found in other bacteria, archaeabacteria and a series of baculoviral proteins. As part of a structural genomics project, the structure of ChaB was elucidated by NMR spectroscopy. RESULTS: The structure of ChaB is composed of 3 alpha-helices and a small sheet that pack tightly to form a fold that is found in the cyclin-box family of proteins. CONCLUSION: ChaB is distinguished from its putative DNA binding sequence homologues by a highly charged flexible loop region that has weak affinity to Mg2+ and Ca2+ divalent metal ions.
The solution structure of ChaB, a putative membrane ion antiporter regulator from Escherichia coli.,Osborne MJ, Siddiqui N, Iannuzzi P, Gehring K BMC Struct Biol. 2004 Aug 11;4:9. PMID:15306028<ref>PMID:15306028</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1sg7" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Cygler M]]
[[Category: Cygler, M]]
[[Category: Gehring K]]
[[Category: Gehring, K]]
[[Category: Osborne MJ]]
[[Category: Osborne, M J]]
[[Category: Siddiqui N]]
[[Category: Siddiqui, N]]
[[Category: Bsgi]]
[[Category: Unknown function]]
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