1wi9: Difference between revisions

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==Solution structure of the PCI domain from mouse hypothetical protein AAH51541==
==Solution structure of the PCI domain from mouse hypothetical protein AAH51541==
<StructureSection load='1wi9' size='340' side='right'caption='[[1wi9]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1wi9' size='340' side='right'caption='[[1wi9]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wi9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WI9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wi9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WI9 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 1110001I20 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi9 OCA], [https://pdbe.org/1wi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wi9 RCSB], [https://www.ebi.ac.uk/pdbsum/1wi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi9 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wi9 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi9 OCA], [https://pdbe.org/1wi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wi9 RCSB], [https://www.ebi.ac.uk/pdbsum/1wi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi9 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wi9 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DDRGK_MOUSE DDRGK_MOUSE]] Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIB, the inhibitor of NF-kappa-B (By similarity). May also play a role in the cellular response to endoplasmic reticulum stress (PubMed:21494687).[UniProtKB:Q96HY6]<ref>PMID:21494687</ref>
[https://www.uniprot.org/uniprot/DDRGK_MOUSE DDRGK_MOUSE] Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIB, the inhibitor of NF-kappa-B (By similarity). May also play a role in the cellular response to endoplasmic reticulum stress (PubMed:21494687).[UniProtKB:Q96HY6]<ref>PMID:21494687</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Inoue, M]]
[[Category: Inoue M]]
[[Category: Kigawa, T]]
[[Category: Kigawa T]]
[[Category: Muto, Y]]
[[Category: Muto Y]]
[[Category: Structural genomic]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M]]
[[Category: Suzuki S]]
[[Category: Suzuki, S]]
[[Category: Terada T]]
[[Category: Terada, T]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Helix-turn-helix motif]]
[[Category: Rsgi]]
[[Category: Unknown function]]
Retrieved from "https://proteopedia.org/1wi9"