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==Solution structure of the antigenic domain of GNA1870 of Neisseria meningitidis==
==Solution structure of the antigenic domain of GNA1870 of Neisseria meningitidis==
<StructureSection load='1ys5' size='340' side='right'caption='[[1ys5]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
<StructureSection load='1ys5' size='340' side='right'caption='[[1ys5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ys5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"diplokokkus_intracellularis_meningitidis"_(sic)_weichselbaum_1887 "diplokokkus intracellularis meningitidis" (sic) weichselbaum 1887]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YS5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ys5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YS5 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gna1870 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 "Diplokokkus intracellularis meningitidis" (sic) Weichselbaum 1887])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ys5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ys5 OCA], [https://pdbe.org/1ys5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ys5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ys5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ys5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ys5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ys5 OCA], [https://pdbe.org/1ys5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ys5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ys5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ys5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FHBP_NEIMB FHBP_NEIMB] A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N.meningitidis. Binding of fH to the bacteria surface is independent of bacterial sialic acid moieties (PubMed:16751403). fH binding affinity is high enough that it may sequester plasma fH, depleting its circulating levels and de-regulating complement in the host (Probable). This protein induces high levels of bactericidal antibodies in mice (PubMed:12642606, PubMed:15039331, PubMed:15664958, PubMed:21753121, PubMed:23133374).<ref>PMID:12642606</ref> <ref>PMID:15039331</ref> <ref>PMID:15664958</ref> <ref>PMID:16751403</ref> <ref>PMID:21753121</ref> <ref>PMID:23133374</ref> <ref>PMID:19225461</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Banci, L]]
[[Category: Neisseria meningitidis]]
[[Category: Cantini, F]]
[[Category: Banci L]]
[[Category: Masignani, V]]
[[Category: Cantini F]]
[[Category: Pizza, M]]
[[Category: Masignani V]]
[[Category: Rappuoli, R]]
[[Category: Pizza M]]
[[Category: Romagnoli, G]]
[[Category: Rappuoli R]]
[[Category: Savino, S]]
[[Category: Romagnoli G]]
[[Category: Scarselli, M]]
[[Category: Savino S]]
[[Category: Swennen, E]]
[[Category: Scarselli M]]
[[Category: Veggi, D]]
[[Category: Swennen E]]
[[Category: Beta-barrel structure]]
[[Category: Veggi D]]
[[Category: Neisseria meningitidi]]
[[Category: Signaling protein]]
[[Category: Vaccine candidate]]
Retrieved from "https://proteopedia.org/1ys5"