1gjs: Difference between revisions

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[[Image:1gjs.gif|left|200px]]
{{Seed}}
[[Image:1gjs.png|left|200px]]


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{{STRUCTURE_1gjs|  PDB=1gjs  |  SCENE=  }}  
{{STRUCTURE_1gjs|  PDB=1gjs  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE ALBUMIN BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G'''
===SOLUTION STRUCTURE OF THE ALBUMIN BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G===




==Overview==
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We have determined the solution structure of an albumin binding domain of protein G, a surface protein of group C and G streptococci. We find that it folds into a left handed three-helix bundle similar to the albumin binding domain of protein PAB from Peptostreptococcus magnus. The two domains share 59% sequence identity, are thermally very stable, and bind to the same site on human serum albumin. The albumin binding site, the first determined for this structural motif known as the GA module, comprises residues spanning the first loop to the beginning of the third helix and includes the most conserved region of GA modules. The two GA modules have different affinities for albumin from different species, and their albumin binding patterns correspond directly to the host specificity of C/G streptococci and P. magnus, respectively. These studies of the evolution, structure, and binding properties of the GA module emphasize the power of bacterial adaptation and underline ecological and medical problems connected with the use of antibiotics.
The line below this paragraph, {{ABSTRACT_PUBMED_11751858}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11751858 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11751858}}


==About this Structure==
==About this Structure==
1GJS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJS OCA].  
1GJS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJS OCA].  


==Reference==
==Reference==
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[[Category: Bacterial surface protein]]
[[Category: Bacterial surface protein]]
[[Category: Protein g]]
[[Category: Protein g]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:39:46 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:24:11 2008''

Revision as of 02:24, 1 July 2008

File:1gjs.png

Template:STRUCTURE 1gjs

SOLUTION STRUCTURE OF THE ALBUMIN BINDING DOMAIN OF STREPTOCOCCAL PROTEIN G

Template:ABSTRACT PUBMED 11751858

About this Structure

1GJS is a Single protein structure of sequence from Bacteria. Full experimental information is available from OCA.

Reference

Structure, specificity, and mode of interaction for bacterial albumin-binding modules., Johansson MU, Frick IM, Nilsson H, Kraulis PJ, Hober S, Jonasson P, Linhult M, Nygren PA, Uhlen M, Bjorck L, Drakenberg T, Forsen S, Wikstrom M, J Biol Chem. 2002 Mar 8;277(10):8114-20. Epub 2001 Dec 18. PMID:11751858

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