7qya: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7qya is ~~ON HOLD until Paper Publication~~

==Proteasome-ZFAND5 Complex Z-B state==

~~Authors~~: ~~Zhu~~, Y., Lu, Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[7qya]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QYA FirstGlance]. <br>

~~Description~~: ~~Proteasome~~-~~ZFAND5 Complex Z~~-~~B state~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qya OCA], [https://pdbe.org/7qya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qya RCSB], [https://www.ebi.ac.uk/pdbsum/7qya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qya ProSAT]</span></td></tr>

[[Category: Lu, Y]]

</table>

[[Category: Zhu, Y]]

== Function ==

[https://www.uniprot.org/uniprot/PSDE_HUMAN PSDE_HUMAN] Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.<ref>PMID:22909820</ref> <ref>PMID:9374539</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Lu Y]]

[[Category: Zhu Y]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7qya is ON HOLD  until Paper Publication
+==Proteasome-ZFAND5 Complex Z-B state==
+<StructureSection load='7qya' size='340' side='right'caption='[[7qya]], [[Resolution|resolution]] 4.80&Aring;' scene=''>
-Authors: Zhu, Y., Lu, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7qya]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QYA FirstGlance]. <br>
-Description: Proteasome-ZFAND5 Complex Z-B state
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qya OCA], [https://pdbe.org/7qya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qya RCSB], [https://www.ebi.ac.uk/pdbsum/7qya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qya ProSAT]</span></td></tr>
-[[Category: Lu, Y]]
+</table>
-[[Category: Zhu, Y]]
+== Function ==
+[https://www.uniprot.org/uniprot/PSDE_HUMAN PSDE_HUMAN] Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.<ref>PMID:22909820</ref> <ref>PMID:9374539</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Lu Y]]
+[[Category: Zhu Y]]