1gl4: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1gl4.jpg|left|200px]]
{{Seed}}
[[Image:1gl4.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1gl4|  PDB=1gl4  |  SCENE=  }}  
{{STRUCTURE_1gl4|  PDB=1gl4  |  SCENE=  }}  


'''NIDOGEN-1 G2/PERLECAN IG3 COMPLEX'''
===NIDOGEN-1 G2/PERLECAN IG3 COMPLEX===




==Overview==
<!--
Nidogen and perlecan are large multifunctional basement membrane (BM) proteins conserved in all metazoa. Their high-affinity interaction, which is likely to contribute to BM assembly and function, is mediated by the central G2 domain in nidogen and the third immunoglobulin (IG)-like domain in perlecan, IG3. We have solved the crystal structure at 2.0 A resolution of the mouse nidogen-1 G2-perlecan IG3 complex. Perlecan IG3 belongs to the I-set of the IG superfamily and binds to the wall of the nidogen-1 G2 beta-barrel using beta-strands C, D and F. Nidogen-1 residues participating in the extensive interface are highly conserved, whereas the corresponding binding site on perlecan is more variable. We hypothesize that a second, as yet unidentified, activity of nidogen overlaps with perlecan binding and accounts for the unusually high degree of surface conservation in the G2 domain.
The line below this paragraph, {{ABSTRACT_PUBMED_11574465}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11574465 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_11574465}}


==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Immunoglobulin-like domain]]
[[Category: Immunoglobulin-like domain]]
[[Category: Proteoglycan]]
[[Category: Proteoglycan]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:42:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:27:55 2008''

Revision as of 02:27, 1 July 2008

File:1gl4.png

Template:STRUCTURE 1gl4

NIDOGEN-1 G2/PERLECAN IG3 COMPLEX

Template:ABSTRACT PUBMED 11574465

About this Structure

1GL4 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan., Kvansakul M, Hopf M, Ries A, Timpl R, Hohenester E, EMBO J. 2001 Oct 1;20(19):5342-6. PMID:11574465

Page seeded by OCA on Tue Jul 1 05:27:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1gl4&oldid=602711"