1e07: Difference between revisions

Line 1:

[[Image:1e07.gif|left|200px]]<br />

[[Image:1e07.gif|left|200px]]<br /><applet load="1e07" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1e07" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1e07" />

'''THEORETICAL MODEL OF HUMAN CARCINOEMBRYONIC ANTIGEN BY HOMOLOGY MODELLING AND CURVE-FITTING TO EXPERIMENTAL SOLUTION SCATTERING DATA'''<br />

==Overview==

MFE23 is a single chain Fv antibody that has a high affinity for, carcinoembryonic antigen (CEA). A full homology model for CEA based on, V-type, I-type and C2-type immunoglobulin folds, 28 oligosaccharides and, the interdomain angle of CD2 was validated using solution scattering data., The superimposition of the intermolecular contacts observed in our recent, crystal structure of MFE23 with the N-terminal domain of CEA permitted the, MFE23-CEA complex to be modelled. Good surface and electrostatic, complementarity and carbohydrate-unhindered access of MFE23 with the, indentation between the first two CEA domains was observed. The model is, supported by biochemical data and provides insight on the high affinity of, MFE23 for CEA.

MFE23 is a single chain Fv antibody that has a high affinity for carcinoembryonic antigen (CEA). A full homology model for CEA based on V-type, I-type and C2-type immunoglobulin folds, 28 oligosaccharides and the interdomain angle of CD2 was validated using solution scattering data. The superimposition of the intermolecular contacts observed in our recent crystal structure of MFE23 with the N-terminal domain of CEA permitted the MFE23-CEA complex to be modelled. Good surface and electrostatic complementarity and carbohydrate-unhindered access of MFE23 with the indentation between the first two CEA domains was observed. The model is supported by biochemical data and provides insight on the high affinity of MFE23 for CEA.

==About this Structure==

1E07 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1E07 OCA].

1E07 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E07 OCA].

==Reference==

Line 14:

Line 13:

[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Boehm, M.K.]]

[[Category: Boehm, M K.]]

[[Category: Perkins, S.J.]]

[[Category: Perkins, S J.]]

[[Category: calpha only]]

[[Category: cea]]

Line 21:

Line 20:

[[Category: tumour marker]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 16:38:~~05 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:22:30 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1e07.gif|left|200px]]<br />
+[[Image:1e07.gif|left|200px]]<br /><applet load="1e07" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1e07" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1e07" />
 '''THEORETICAL MODEL OF HUMAN CARCINOEMBRYONIC ANTIGEN BY HOMOLOGY MODELLING AND CURVE-FITTING TO EXPERIMENTAL SOLUTION SCATTERING DATA'''<br />
 ==Overview==
-MFE23 is a single chain Fv antibody that has a high affinity for, carcinoembryonic antigen (CEA). A full homology model for CEA based on, V-type, I-type and C2-type immunoglobulin folds, 28 oligosaccharides and, the interdomain angle of CD2 was validated using solution scattering data., The superimposition of the intermolecular contacts observed in our recent, crystal structure of MFE23 with the N-terminal domain of CEA permitted the, MFE23-CEA complex to be modelled. Good surface and electrostatic, complementarity and carbohydrate-unhindered access of MFE23 with the, indentation between the first two CEA domains was observed. The model is, supported by biochemical data and provides insight on the high affinity of, MFE23 for CEA.
+MFE23 is a single chain Fv antibody that has a high affinity for carcinoembryonic antigen (CEA). A full homology model for CEA based on V-type, I-type and C2-type immunoglobulin folds, 28 oligosaccharides and the interdomain angle of CD2 was validated using solution scattering data. The superimposition of the intermolecular contacts observed in our recent crystal structure of MFE23 with the N-terminal domain of CEA permitted the MFE23-CEA complex to be modelled. Good surface and electrostatic complementarity and carbohydrate-unhindered access of MFE23 with the indentation between the first two CEA domains was observed. The model is supported by biochemical data and provides insight on the high affinity of MFE23 for CEA.
 ==About this Structure==
-E07 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E07 OCA].
+E07 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E07 OCA].
 ==Reference==
@@ Line 14: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Boehm, M.K.]]
+[[Category: Boehm, M K.]]
-[[Category: Perkins, S.J.]]
+[[Category: Perkins, S J.]]
 [[Category: calpha only]]
 [[Category: cea]]
@@ Line 21: / Line 20: @@
 [[Category: tumour marker]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:38:05 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:22:30 2008''