1gln: Difference between revisions

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[[Image:1gln.~~gif~~|left|200px]]

[[Image:1gln.png|left|200px]]

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~~'''~~ARCHITECTURES OF CLASS-DEFINING AND SPECIFIC DOMAINS OF GLUTAMYL-TRNA SYNTHETASE~~'''~~

===ARCHITECTURES OF CLASS-DEFINING AND SPECIFIC DOMAINS OF GLUTAMYL-TRNA SYNTHETASE===

~~==Overview==~~

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The ~~crystal structure of a class I aminoacyl-transfer RNA synthetase~~, ~~glutamyl-tRNA synthetase (GluRS) from Thermus thermophilus~~, was solved and refined at 2.5 A resolution. The amino-terminal half of GluRS shows a geometrical similarity with that of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) of the same subclass in class I, comprising the class I-specific Rossmann fold domain and the ~~intervening subclass-specific alpha/beta domain. These domains were found~~ to ~~have two GluRS-specific, secondary-structure insertions, which then participated in~~ the ~~specific recognition of the D and acceptor stems of tRNA~~(~~Glu)~~ as ~~indicated by mutagenesis analyses based~~ on ~~the docking properties of GluRS and tRNA~~. ~~In striking contrast to the beta-barrel structure of the GlnRS carboxyl-terminal half~~, the ~~GluRS carboxyl~~-~~terminal half displayed an all~~-~~alpha-helix architecture, an alpha-helix cage, and mutagenesis analyses indicated that it had a role in the anticodon recognition.~~

The line below this paragraph, {{ABSTRACT_PUBMED_7701318}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 7701318 is the PubMed ID number.

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==About this Structure==

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[[Category: Rsgi]]

[[Category: Structural genomic]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 17~~:43:49 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:29:24 2008''

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-[[Image:1gln.gif|left|200px]]
+{{Seed}}
+[[Image:1gln.png|left|200px]]
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 {{STRUCTURE_1gln|  PDB=1gln  |  SCENE=  }}
-'''ARCHITECTURES OF CLASS-DEFINING AND SPECIFIC DOMAINS OF GLUTAMYL-TRNA SYNTHETASE'''
+===ARCHITECTURES OF CLASS-DEFINING AND SPECIFIC DOMAINS OF GLUTAMYL-TRNA SYNTHETASE===
-==Overview==
+<!--
-The crystal structure of a class I aminoacyl-transfer RNA synthetase, glutamyl-tRNA synthetase (GluRS) from Thermus thermophilus, was solved and refined at 2.5 A resolution. The amino-terminal half of GluRS shows a geometrical similarity with that of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) of the same subclass in class I, comprising the class I-specific Rossmann fold domain and the intervening subclass-specific alpha/beta domain. These domains were found to have two GluRS-specific, secondary-structure insertions, which then participated in the specific recognition of the D and acceptor stems of tRNA(Glu) as indicated by mutagenesis analyses based on the docking properties of GluRS and tRNA. In striking contrast to the beta-barrel structure of the GlnRS carboxyl-terminal half, the GluRS carboxyl-terminal half displayed an all-alpha-helix architecture, an alpha-helix cage, and mutagenesis analyses indicated that it had a role in the anticodon recognition.
+The line below this paragraph, {{ABSTRACT_PUBMED_7701318}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 7701318 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_7701318}}
 ==About this Structure==
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 [[Category: Rsgi]]
 [[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 17:43:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 05:29:24 2008''