7mk2: Difference between revisions
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==CryoEM Structure of NPR1== | ==CryoEM Structure of NPR1== | ||
<StructureSection load='7mk2' size='340' side='right'caption='[[7mk2]]' scene=''> | <StructureSection load='7mk2' size='340' side='right'caption='[[7mk2]], [[Resolution|resolution]] 3.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MK2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7mk2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MK2 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mk2 OCA], [https://pdbe.org/7mk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mk2 RCSB], [https://www.ebi.ac.uk/pdbsum/7mk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mk2 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mk2 OCA], [https://pdbe.org/7mk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mk2 RCSB], [https://www.ebi.ac.uk/pdbsum/7mk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mk2 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/NPR1_ARATH NPR1_ARATH]] May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, a biphasic change in cellular reduction potential occurs, resulting in reduction of the cytoplasmic oligomeric form to a monomeric form that accumulates in the nucleus and activates gene expression. Phosphorylated form is target of proteasome degradation.<ref>PMID:11607555</ref> <ref>PMID:12615947</ref> <ref>PMID:12837250</ref> <ref>PMID:12897257</ref> <ref>PMID:12953119</ref> <ref>PMID:9002272</ref> <ref>PMID:9019406</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bartesaghi A]] | [[Category: Bartesaghi, A]] | ||
[[Category: Borgnia M]] | [[Category: Borgnia, M]] | ||
[[Category: Dillard L]] | [[Category: Dillard, L]] | ||
[[Category: Kumar S]] | [[Category: Kumar, S]] | ||
[[Category: Zhou P]] | [[Category: Zhou, P]] | ||
[[Category: Zhou Y]] | [[Category: Zhou, Y]] | ||
[[Category: Immune system]] | |||
[[Category: Npr1]] | |||
[[Category: Plant immunity]] | |||
[[Category: Plant protein]] | |||
[[Category: Sar]] | |||
