7p6s: Difference between revisions
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==Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form II)== | ==Crystal structure of the FimH-binding decoy module of human glycoprotein 2 (GP2) (crystal form II)== | ||
<StructureSection load='7p6s' size='340' side='right'caption='[[7p6s]]' scene=''> | <StructureSection load='7p6s' size='340' side='right'caption='[[7p6s]], [[Resolution|resolution]] 1.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P6S FirstGlance]. <br> | <table><tr><td colspan='2'>[[7p6s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P6S FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p6s OCA], [https://pdbe.org/7p6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p6s RCSB], [https://www.ebi.ac.uk/pdbsum/7p6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p6s ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9JE:pentane-1,5-diol'>9JE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7p6r|7p6r]], [[7p6t|7p6t]]</div></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p6s OCA], [https://pdbe.org/7p6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p6s RCSB], [https://www.ebi.ac.uk/pdbsum/7p6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p6s ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/GP2_HUMAN GP2_HUMAN]] Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.<ref>PMID:19907495</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these proteins contain a bipartite decoy module whose new fold presents the high-mannose glycan recognized by FimH. The structure rationalizes UMOD mutations associated with kidney diseases and visualizes a key epitope implicated in cast nephropathy. | |||
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.,Stsiapanava A, Xu C, Nishio S, Han L, Yamakawa N, Carroni M, Tunyasuvunakool K, Jumper J, de Sanctis D, Wu B, Jovine L Nat Struct Mol Biol. 2022 Mar;29(3):190-193. doi: 10.1038/s41594-022-00729-3., Epub 2022 Mar 10. PMID:35273390<ref>PMID:35273390</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7p6s" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Jovine L]] | [[Category: Jovine, L]] | ||
[[Category: Jumper J]] | [[Category: Jumper, J]] | ||
[[Category: Stsiapanava A]] | [[Category: Sanctis, D de]] | ||
[[Category: Tunyasuvunakool K]] | [[Category: Stsiapanava, A]] | ||
[[Category: | [[Category: Tunyasuvunakool, K]] | ||
[[Category: Alphafold]] | |||
[[Category: Antimicrobial protein]] | |||
[[Category: D10c domain]] | |||
[[Category: D8c sequence]] | |||
[[Category: Decoy module]] | |||
[[Category: Extracellular matrix]] | |||
[[Category: Fimh]] | |||
[[Category: Glycoprotein]] | |||
[[Category: Intestine]] | |||
[[Category: Mucosal immunity]] | |||
[[Category: N-glycan]] | |||
[[Category: Pancrea]] | |||
[[Category: Structural protein]] | |||
