7ra9: Difference between revisions
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==Designed StabIL-2 seq1== | ==Designed StabIL-2 seq1== | ||
<StructureSection load='7ra9' size='340' side='right'caption='[[7ra9]]' scene=''> | <StructureSection load='7ra9' size='340' side='right'caption='[[7ra9]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RA9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7ra9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RA9 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ra9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ra9 OCA], [https://pdbe.org/7ra9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ra9 RCSB], [https://www.ebi.ac.uk/pdbsum/7ra9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ra9 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ra9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ra9 OCA], [https://pdbe.org/7ra9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ra9 RCSB], [https://www.ebi.ac.uk/pdbsum/7ra9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ra9 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chu | [[Category: Chu, A E]] | ||
[[Category: Garcia | [[Category: Garcia, K C]] | ||
[[Category: Huang P | [[Category: Huang, P S]] | ||
[[Category: Jude | [[Category: Jude, K M]] | ||
[[Category: Cytokine]] | |||
[[Category: Synthetic protein]] | |||
