7wi6: Difference between revisions
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==Cryo-EM structure of LY341495/NAM-bound mGlu3== | ==Cryo-EM structure of LY341495/NAM-bound mGlu3== | ||
<StructureSection load='7wi6' size='340' side='right'caption='[[7wi6]]' scene=''> | <StructureSection load='7wi6' size='340' side='right'caption='[[7wi6]], [[Resolution|resolution]] 3.71Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WI6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7wi6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WI6 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wi6 OCA], [https://pdbe.org/7wi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wi6 RCSB], [https://www.ebi.ac.uk/pdbsum/7wi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wi6 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wi6 OCA], [https://pdbe.org/7wi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wi6 RCSB], [https://www.ebi.ac.uk/pdbsum/7wi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wi6 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Fang W]] | [[Category: Fang, W]] | ||
[[Category: Lin L]] | [[Category: Lin, L]] | ||
[[Category: Ling | [[Category: Ling, S L]] | ||
[[Category: Liu | [[Category: Liu, J F]] | ||
[[Category: Liu P]] | [[Category: Liu, P]] | ||
[[Category: Pan S]] | [[Category: Pan, S]] | ||
[[Category: Pin | [[Category: Pin, J P]] | ||
[[Category: Rondard P]] | [[Category: Rondard, P]] | ||
[[Category: Sun | [[Category: Sun, W J]] | ||
[[Category: Tian | [[Category: Tian, C L]] | ||
[[Category: Wang | [[Category: Wang, X M]] | ||
[[Category: Xu | [[Category: Xu, C J]] | ||
[[Category: Yang F]] | [[Category: Yang, F]] | ||
[[Category: Zhou | [[Category: Zhou, Y X]] | ||
[[Category: Cryo-em]] | |||
[[Category: G protein-coupled receptor]] | |||
[[Category: Glutamate]] | |||
[[Category: Membrane protein]] | |||
[[Category: Selective ligand]] | |||
Revision as of 07:18, 20 July 2022
Cryo-EM structure of LY341495/NAM-bound mGlu3
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