3gqq: Difference between revisions
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==Crystal structure of the human retinal protein 4 (unc-119 homolog A). Northeast Structural Genomics Consortium target HR3066a== | ==Crystal structure of the human retinal protein 4 (unc-119 homolog A). Northeast Structural Genomics Consortium target HR3066a== | ||
<StructureSection load='3gqq' size='340' side='right'caption='[[3gqq]], [[Resolution|resolution]] 1. | <StructureSection load='3gqq' size='340' side='right'caption='[[3gqq]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3gqq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3gqq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GQQ FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.945Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqq OCA], [https://pdbe.org/3gqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gqq RCSB], [https://www.ebi.ac.uk/pdbsum/3gqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gqq ProSAT], [https://www.topsan.org/Proteins/NESGC/3gqq TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqq OCA], [https://pdbe.org/3gqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gqq RCSB], [https://www.ebi.ac.uk/pdbsum/3gqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gqq ProSAT], [https://www.topsan.org/Proteins/NESGC/3gqq TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/U119A_HUMAN U119A_HUMAN] Idiopathic CD4 lymphocytopenia;Cone rod dystrophy. Defects in UNC119 may be a cause of cone-rod dystrophy. A mutation was found in a 57-year-old woman with late-onset cone-rod dystrophy: from 40 year old, the patient suffered from poor night vision, defective color vision and light-sensitivity. At 57 year old, she displayed reduced visual acuity, myopa, macular atrophy and pericentral ring scotomas. The disease was caused by a heterozygous mutation causing premature termination and truncated UNC119 protein with dominant-negative effect. | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/U119A_HUMAN U119A_HUMAN] Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Binds myristoylated NPHP3; however, in contrast to UNC119B, does not seem to play a major role in ciliary membrane localization of NPHP3. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.<ref>PMID:22085962</ref> <ref>PMID:21642972</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/3gqq_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/3gqq_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Acton | [[Category: Acton TB]] | ||
[[Category: Chen | [[Category: Chen Y]] | ||
[[Category: Ciccosanti | [[Category: Ciccosanti C]] | ||
[[Category: Foote | [[Category: Foote EL]] | ||
[[Category: Hunt | [[Category: Hunt JF]] | ||
[[Category: Montelione | [[Category: Montelione GT]] | ||
[[Category: Sahdev S]] | |||
[[Category: Sahdev | [[Category: Seetharaman J]] | ||
[[Category: Seetharaman | [[Category: Shastry R]] | ||
[[Category: Shastry | [[Category: Tong L]] | ||
[[Category: Tong | [[Category: Vorobiev SM]] | ||
[[Category: Vorobiev | [[Category: Xiao R]] | ||
[[Category: Xiao | |||
