1gnh: Difference between revisions

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[[Image:1gnh.gif|left|200px]]
{{Seed}}
[[Image:1gnh.png|left|200px]]


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{{STRUCTURE_1gnh|  PDB=1gnh  |  SCENE=  }}  
{{STRUCTURE_1gnh|  PDB=1gnh  |  SCENE=  }}  


'''HUMAN C-REACTIVE PROTEIN'''
===HUMAN C-REACTIVE PROTEIN===




==Overview==
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The structure of the classical acute phase reactant human C-reactive protein provides evidence that phosphocholine binding is mediated through calcium and a hydrophobic pocket centred on Phe 66. The residue Glu 81 is suitably positioned to interact with the choline group. A cleft on the pentameric face opposite to that containing the calcium site may have an important functional role. The structure provides insights into the molecular mechanisms by which this highly conserved plasma protein, for which no polymorphism or deficiency state is known, may exert its biological role.
The line below this paragraph, {{ABSTRACT_PUBMED_8599761}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8599761 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8599761}}


==About this Structure==
==About this Structure==
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[[Category: Acute-phase reactant]]
[[Category: Acute-phase reactant]]
[[Category: Pentraxin]]
[[Category: Pentraxin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:47:08 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:33:37 2008''
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