Sandbox Reserved 1724: Difference between revisions

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==Vitamin K Epoxide Reductase==

~~This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.~~

~~You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.~~

== Introduction ==

Vitamin K epoxide reductase (VKOR) is the enzyme responsible for regenerating vitamin K from vitamin K epoxide to support blood coagulation.

=== Vitamin K Cycle ===

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===~~Tyrosine 138 and Asparagine 80~~===

===Catalytic Amino Acids===

VKOR uses two catalytic amino acids, tyrosine 139 and asparagine 80, to stabilize vitamin K in all forms and vitamin K antagonists, such as warfarin, in the binding pocket. Tyr139 and Asn80 hydrogen bond to carbonyl groups on both structures and stabilizes them within the binding pocket.

===Hydrophobic Interactions===

Other than the two previously mentioned hydrogen bonds (Tyr139 and Asn80), vitamin K and antagonists are bound in via hydrophobic interactions within the binding pocket of VKOR. Hydrophobic residues of VKOR such as Phe80, Phe87, and Tyr88, form a hydrophobic tunnel within the binding pocket.

== Medical Relevance ==

Sandbox Reserved 1724: Difference between revisions

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 ==Vitamin K Epoxide Reductase==
 <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
-This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Introduction ==
+Vitamin K epoxide reductase (VKOR) is the enzyme responsible for regenerating vitamin K from vitamin K epoxide to support blood coagulation.
 === Vitamin K Cycle ===
@@ Line 24: / Line 23: @@
-===Tyrosine 138 and Asparagine 80===
+===Catalytic Amino Acids===
+VKOR uses two catalytic amino acids, tyrosine 139 and asparagine 80, to stabilize vitamin K in all forms and vitamin K antagonists, such as warfarin, in the binding pocket. Tyr139 and Asn80 hydrogen bond to carbonyl groups on both structures and stabilizes them within the binding pocket.
 ===Hydrophobic Interactions===
+Other than the two previously mentioned hydrogen bonds (Tyr139 and Asn80), vitamin K and antagonists are bound in via hydrophobic interactions within the binding pocket of VKOR. Hydrophobic residues of VKOR such as Phe80, Phe87, and Tyr88, form a hydrophobic tunnel within the binding pocket.
 == Medical Relevance ==