1e31: Difference between revisions

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[[Image:1e31.gif|left|200px]]<br />

[[Image:1e31.gif|left|200px]]<br /><applet load="1e31" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1e31" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1e31, resolution 2.71Å" />

'''SURVIVIN DIMER H. SAPIENS'''<br />

==Overview==

Survivin is a mitotic spindle-associated protein involved in linking, mitotic spindle function to activation of apoptosis in mammalian cells., The structure of the full-length human survivin has been determined by, X-ray crystallography to 2.7 A. Strikingly, the structure forms a very, unusual bow tie-shaped dimer. It does not dimerize through a C-terminal, coiled-coil, contrary to sequence analysis prediction. The C-terminal, helices contain hydrophobic clusters with the potential for, protein-protein interactions. The unusual shape and dimensions of survivin, suggest it serves an adaptor function through its alpha-helical, extensions.

Survivin is a mitotic spindle-associated protein involved in linking mitotic spindle function to activation of apoptosis in mammalian cells. The structure of the full-length human survivin has been determined by X-ray crystallography to 2.7 A. Strikingly, the structure forms a very unusual bow tie-shaped dimer. It does not dimerize through a C-terminal coiled-coil, contrary to sequence analysis prediction. The C-terminal helices contain hydrophobic clusters with the potential for protein-protein interactions. The unusual shape and dimensions of survivin suggest it serves an adaptor function through its alpha-helical extensions.

==About this Structure==

1E31 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and CO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1E31 OCA].

1E31 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CO:'>CO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E31 OCA].

==Reference==

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[[Category: zinc finger]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 16:39:~~11 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:23:14 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1e31.gif|left|200px]]<br />
+[[Image:1e31.gif|left|200px]]<br /><applet load="1e31" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1e31" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1e31, resolution 2.71&Aring;" />
 '''SURVIVIN DIMER H. SAPIENS'''<br />
 ==Overview==
-Survivin is a mitotic spindle-associated protein involved in linking, mitotic spindle function to activation of apoptosis in mammalian cells., The structure of the full-length human survivin has been determined by, X-ray crystallography to 2.7 A. Strikingly, the structure forms a very, unusual bow tie-shaped dimer. It does not dimerize through a C-terminal, coiled-coil, contrary to sequence analysis prediction. The C-terminal, helices contain hydrophobic clusters with the potential for, protein-protein interactions. The unusual shape and dimensions of survivin, suggest it serves an adaptor function through its alpha-helical, extensions.
+Survivin is a mitotic spindle-associated protein involved in linking mitotic spindle function to activation of apoptosis in mammalian cells. The structure of the full-length human survivin has been determined by X-ray crystallography to 2.7 A. Strikingly, the structure forms a very unusual bow tie-shaped dimer. It does not dimerize through a C-terminal coiled-coil, contrary to sequence analysis prediction. The C-terminal helices contain hydrophobic clusters with the potential for protein-protein interactions. The unusual shape and dimensions of survivin suggest it serves an adaptor function through its alpha-helical extensions.
 ==About this Structure==
-E31 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and CO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E31 OCA].
+E31 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CO:'>CO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E31 OCA].
 ==Reference==
@@ Line 24: / Line 23: @@
 [[Category: zinc finger]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:39:11 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:23:14 2008''