7x8x: Difference between revisions
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==structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease== | |||
<StructureSection load='7x8x' size='340' side='right'caption='[[7x8x]], [[Resolution|resolution]] 3.24Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7x8x]] is a 56 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis], [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CDC1551 Mycobacterium tuberculosis CDC1551] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X8X FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AI4:4-[1-[3-[4-[(4-fluoranyl-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-quinazolin-7-yl]oxypropyl]piperidin-4-yl]benzamide'>AI4</scene>, <scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x8x OCA], [https://pdbe.org/7x8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x8x RCSB], [https://www.ebi.ac.uk/pdbsum/7x8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x8x ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Luo | == Function == | ||
[[Category: Yang | [https://www.uniprot.org/uniprot/CLPP2_MYCTO CLPP2_MYCTO] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.[HAMAP-Rule:MF_00444] | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Mycobacterium tuberculosis CDC1551]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Bao R]] | |||
[[Category: Luo YF]] | |||
[[Category: Yang Y]] | |||
[[Category: Zhou YZ]] | |||
[[Category: Zhu YB]] | |||
Revision as of 20:27, 12 April 2023
structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease
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