7nr6: Difference between revisions
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==Structure of NUDT15 in complex with NSC56456== | ==Structure of NUDT15 in complex with NSC56456== | ||
<StructureSection load='7nr6' size='340' side='right'caption='[[7nr6]]' scene=''> | <StructureSection load='7nr6' size='340' side='right'caption='[[7nr6]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NR6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7nr6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NR6 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nr6 OCA], [https://pdbe.org/7nr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nr6 RCSB], [https://www.ebi.ac.uk/pdbsum/7nr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nr6 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UO8:2-azanyl-9-cyclohexyl-3~{H}-purine-6-thione'>UO8</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nr6 OCA], [https://pdbe.org/7nr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nr6 RCSB], [https://www.ebi.ac.uk/pdbsum/7nr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nr6 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NUD15_HUMAN NUD15_HUMAN] Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.<ref>PMID:19419956</ref> <ref>PMID:22556419</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Rehling D]] | [[Category: Rehling D]] | ||
[[Category: Stenmark P]] | [[Category: Stenmark P]] | ||
Latest revision as of 12:38, 1 February 2024
Structure of NUDT15 in complex with NSC56456
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