1got: Difference between revisions

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[[Image:1got.gif|left|200px]]
[[Image:1got.png|left|200px]]


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==Overview==
{{ABSTRACT_8552184}}
The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the alpha and beta gamma subunits that regulates their interaction with receptor and effector molecules. The interaction involves two distinct interfaces and dramatically alters the conformation of the alpha but not of the beta gamma subunits. The location of the known sites for post-translational modification and receptor coupling suggest a plausible orientation with respect to the membrane surface and an activated heptahelical receptor.


==About this Structure==
==About this Structure==
1GOT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The following page contains interesting information on the relation of 1GOT with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb58_1.html G Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GOT OCA].  
1GOT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The following page contains interesting information on the relation of 1GOT with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb58_1.html G Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GOT OCA].  
==Reference==
The 2.0 A crystal structure of a heterotrimeric G protein., Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB, Nature. 1996 Jan 25;379(6563):311-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8552184 8552184]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: G Proteins]]
[[Category: G Proteins]]
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[[Category: G protein]]
[[Category: G protein]]
[[Category: Heterotrimer signal transduction]]
[[Category: Heterotrimer signal transduction]]
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