2rsm: Difference between revisions
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==Solution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65 (ICT2)== | ==Solution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65 (ICT2)== | ||
<StructureSection load='2rsm' size='340' side='right'caption='[[2rsm | <StructureSection load='2rsm' size='340' side='right'caption='[[2rsm]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2rsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2rsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RSM FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rsm OCA], [https://pdbe.org/2rsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rsm RCSB], [https://www.ebi.ac.uk/pdbsum/2rsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rsm ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rsm OCA], [https://pdbe.org/2rsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rsm RCSB], [https://www.ebi.ac.uk/pdbsum/2rsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rsm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/MTRFR_MOUSE MTRFR_MOUSE] Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue.[UniProtKB:Q9H3J6] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Enomoto | [[Category: Enomoto M]] | ||
[[Category: Guntert | [[Category: Guntert P]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Koshiba | [[Category: Koshiba S]] | ||
[[Category: Nameki | [[Category: Nameki N]] | ||
[[Category: Tochio | [[Category: Tochio N]] | ||
[[Category: Tomizawa | [[Category: Tomizawa T]] | ||
[[Category: Yokoyama | [[Category: Yokoyama S]] | ||
