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==Structure of metallo-dna in solution==
==Structure of metallo-dna in solution==
<StructureSection load='2rt8' size='340' side='right'caption='[[2rt8]], [[NMR_Ensembles_of_Models | 17 NMR models]]' scene=''>
<StructureSection load='2rt8' size='340' side='right'caption='[[2rt8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2rt8]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RT8 FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RT8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rt8 OCA], [https://pdbe.org/2rt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rt8 RCSB], [https://www.ebi.ac.uk/pdbsum/2rt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rt8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rt8 OCA], [https://pdbe.org/2rt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rt8 RCSB], [https://www.ebi.ac.uk/pdbsum/2rt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rt8 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We have determined the three-dimensional (3D) structure of DNA duplex that includes tandem Hg(II)-mediated T-T base pairs (thymine-Hg(II)-thymine, T-Hg(II)-T) with NMR spectroscopy in solution. This is the first 3D structure of metallo-DNA (covalently metallated DNA) composed exclusively of 'NATURAL' bases. The T-Hg(II)-T base pairs whose chemical structure was determined with the (15)N NMR spectroscopy were well accommodated in a B-form double helix, mimicking normal Watson-Crick base pairs. The Hg atoms aligned along DNA helical axis were shielded from the bulk water. The complete dehydration of Hg atoms inside DNA explained the positive reaction entropy (DeltaS) for the T-Hg(II)-T base pair formation. The positive DeltaS value arises owing to the Hg(II) dehydration, which was approved with the 3D structure. The 3D structure explained extraordinary affinity of thymine towards Hg(II) and revealed arrangement of T-Hg(II)-T base pairs in metallo-DNA.
The structure of metallo-DNA with consecutive thymine-HgII-thymine base pairs explains positive entropy for the metallo base pair formation.,Yamaguchi H, Sebera J, Kondo J, Oda S, Komuro T, Kawamura T, Dairaku T, Kondo Y, Okamoto I, Ono A, Burda JV, Kojima C, Sychrovsky V, Tanaka Y Nucleic Acids Res. 2014 Apr;42(6):4094-9. doi: 10.1093/nar/gkt1344. Epub 2013 Dec, 26. PMID:24371287<ref>PMID:24371287</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2rt8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Burda, J V]]
[[Category: Burda JV]]
[[Category: Dairaku, T]]
[[Category: Dairaku T]]
[[Category: Kawamura, T]]
[[Category: Kawamura T]]
[[Category: Kojima, C]]
[[Category: Kojima C]]
[[Category: Komuro, T]]
[[Category: Komuro T]]
[[Category: Kondo, J]]
[[Category: Kondo J]]
[[Category: Kondo, Y]]
[[Category: Kondo Y]]
[[Category: Oda, S]]
[[Category: Oda S]]
[[Category: Okamoto, I]]
[[Category: Okamoto I]]
[[Category: Ono, A]]
[[Category: Ono A]]
[[Category: Sebera, J]]
[[Category: Sebera J]]
[[Category: Sychrovsky, V]]
[[Category: Sychrovsky V]]
[[Category: Tanaka, Y]]
[[Category: Tanaka Y]]
[[Category: Yamaguchi, H]]
[[Category: Yamaguchi H]]
[[Category: Dna]]
[[Category: Metallo-base-pair]]

Revision as of 10:25, 31 August 2022

Structure of metallo-dna in solution

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