1gp7: Difference between revisions

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[[Image:1gp7.gif|left|200px]]
{{Seed}}
[[Image:1gp7.png|left|200px]]


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{{STRUCTURE_1gp7|  PDB=1gp7  |  SCENE=  }}  
{{STRUCTURE_1gp7|  PDB=1gp7  |  SCENE=  }}  


'''ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH'''
===ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH===




==Overview==
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The crystal structure of an acidic phospholipase A(2) from Ophiophagus hannah (king cobra) has been determined by molecular replacement at 2.6-A resolution to a crystallographic R factor of 20.5% (R(free)=23.3%) with reasonable stereochemistry. The venom enzyme contains an unusual "pancreatic loop." The conformation of the loop is well defined and different from those in pancreas PLA(2), showing its structural variability. This analysis provides the first structure of a PLA(2)-type cardiotoxin. The sites related to the cardiotoxic and myotoxic activities are explored and the oligomer observed in the crystalline state is described.
The line below this paragraph, {{ABSTRACT_PUBMED_12217659}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12217659}}


==About this Structure==
==About this Structure==
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[[Category: Phospholipase a2]]
[[Category: Phospholipase a2]]
[[Category: Snake venom]]
[[Category: Snake venom]]
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