2v4d: Difference between revisions

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<StructureSection load='2v4d' size='340' side='right'caption='[[2v4d]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='2v4d' size='340' side='right'caption='[[2v4d]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2v4d]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4D FirstGlance]. <br>
<table><tr><td colspan='2'>[[2v4d]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vf7|1vf7]], [[1t5e|1t5e]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4d OCA], [https://pdbe.org/2v4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4d RCSB], [https://www.ebi.ac.uk/pdbsum/2v4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4d OCA], [https://pdbe.org/2v4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4d RCSB], [https://www.ebi.ac.uk/pdbsum/2v4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/MEXA_PSEAE MEXA_PSEAE]] The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>  The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>
[https://www.uniprot.org/uniprot/MEXA_PSEAE MEXA_PSEAE] The periplasmic linker component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the MexA/MexB/OprM complex. Implicated in the secretion of the siderophore pyoverdine.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>  The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bokma, E]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Hughes, C]]
[[Category: Bokma E]]
[[Category: Koronakis, E]]
[[Category: Hughes C]]
[[Category: Koronakis, V]]
[[Category: Koronakis E]]
[[Category: Symmons, M F]]
[[Category: Koronakis V]]
[[Category: Antibiotic efflux pump]]
[[Category: Symmons MF]]
[[Category: Antibiotic resistance]]
[[Category: Cell inner membrane]]
[[Category: Cell membrane]]
[[Category: Coiled coil]]
[[Category: Inner membrane]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Membrane protein]]
[[Category: Mexa]]
[[Category: Palmitate]]
[[Category: Periplasmic adaptor protein]]
[[Category: Transport]]
[[Category: Transport protein]]
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