2v9u: Difference between revisions
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<StructureSection load='2v9u' size='340' side='right'caption='[[2v9u]], [[Resolution|resolution]] 2.59Å' scene=''> | <StructureSection load='2v9u' size='340' side='right'caption='[[2v9u]], [[Resolution|resolution]] 2.59Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2v9u]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2v9u]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V9U FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9u OCA], [https://pdbe.org/2v9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v9u RCSB], [https://www.ebi.ac.uk/pdbsum/2v9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9u ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9u OCA], [https://pdbe.org/2v9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v9u RCSB], [https://www.ebi.ac.uk/pdbsum/2v9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v9u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/MSPA_MYCS2 MSPA_MYCS2] The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA channels into the membrane or by the existence of different MspA conformations.<ref>PMID:10476028</ref> <ref>PMID:16238622</ref> <ref>PMID:17209034</ref> <ref>PMID:18559650</ref> <ref>PMID:20952578</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mycolicibacterium smegmatis MC2 155]] | ||
[[Category: Grueninger | [[Category: Grueninger D]] | ||
[[Category: Koetter | [[Category: Koetter JWA]] | ||
[[Category: Schulz | [[Category: Schulz GE]] | ||
[[Category: Schulze | [[Category: Schulze M-S]] | ||
[[Category: Treiber | [[Category: Treiber N]] | ||
[[Category: Ziegler | [[Category: Ziegler MOP]] | ||
