2vas: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[2vas]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Drome Drome~~] and [https://en.wikipedia.org/wiki/~~Pig Pig~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VAS FirstGlance]. <br>

<table><tr><td colspan='2'>[[2vas]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VAS FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr>

~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bkh|2bkh]], [[2v26|2v26]], [[2bki|2bki]]</div~~></td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vas OCA], [https://pdbe.org/2vas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vas RCSB], [https://www.ebi.ac.uk/pdbsum/2vas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vas ProSAT]</span></td></tr>

</table>

== Function ==

[[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref> [[https://www.uniprot.org/uniprot/CALM_DROME CALM_DROME]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.

[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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__TOC__

</StructureSection>

[[Category: ~~Drome~~]]

[[Category: Drosophila melanogaster]]

[[Category: Large Structures]]

[[Category: ~~Pig~~]]

[[Category: Sus scrofa]]

[[Category: Cicolari, J]]

[[Category: Cicolari J]]

[[Category: Houdusse, A]]

[[Category: Houdusse A]]

[[Category: Li, A]]

[[Category: Li A]]

[[Category: Liu, X]]

[[Category: Liu X]]

[[Category: Llinas, P]]

[[Category: Llinas P]]

[[Category: Menetrey, J]]

[[Category: Menetrey J]]

[[Category: Squires, G]]

[[Category: Squires G]]

[[Category: Sweeney~~, H L]]~~

[[Category: Sweeney HL]]

~~[[Category: Actin-binding]]~~

~~[[Category: Atp-binding]]~~

~~[[Category: Calmodulin]]~~

~~[[Category: Calmodulin-binding]]~~

~~[[Category: Cam]]~~

~~[[Category: Coiled coil]]~~

~~[[Category: Cytoplasm]]~~

~~[[Category: Endocytosis]]~~

~~[[Category: Golgi apparatus]]~~

~~[[Category: Membrane]]~~

~~[[Category: Mg adp befx]]~~

~~[[Category: Molecular motor]]~~

~~[[Category: Motor protein]]~~

~~[[Category: Myosin]]~~

~~[[Category: Myosin vi]]~~

~~[[Category: Nucleotide-binding]]~~

~~[[Category: Nucleus]]~~

~~[[Category: Phosphorylation]]~~

~~[[Category: Post-rigor state]]~~

~~[[Category: Protein transport]]~~

~~[[Category: Transport~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='2vas' size='340' side='right'caption='[[2vas]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2vas]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome] and [https://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VAS FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2vas]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VAS FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bkh|2bkh]], [[2v26|2v26]], [[2bki|2bki]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vas OCA], [https://pdbe.org/2vas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vas RCSB], [https://www.ebi.ac.uk/pdbsum/2vas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vas ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref>  [[https://www.uniprot.org/uniprot/CALM_DROME CALM_DROME]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
+[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 37: / Line 37: @@
 __TOC__
 </StructureSection>
-[[Category: Drome]]
+[[Category: Drosophila melanogaster]]
 [[Category: Large Structures]]
-[[Category: Pig]]
+[[Category: Sus scrofa]]
-[[Category: Cicolari, J]]
+[[Category: Cicolari J]]
-[[Category: Houdusse, A]]
+[[Category: Houdusse A]]
-[[Category: Li, A]]
+[[Category: Li A]]
-[[Category: Liu, X]]
+[[Category: Liu X]]
-[[Category: Llinas, P]]
+[[Category: Llinas P]]
-[[Category: Menetrey, J]]
+[[Category: Menetrey J]]
-[[Category: Squires, G]]
+[[Category: Squires G]]
-[[Category: Sweeney, H L]]
+[[Category: Sweeney HL]]
-[[Category: Actin-binding]]
-[[Category: Atp-binding]]
-[[Category: Calmodulin]]
-[[Category: Calmodulin-binding]]
-[[Category: Cam]]
-[[Category: Coiled coil]]
-[[Category: Cytoplasm]]
-[[Category: Endocytosis]]
-[[Category: Golgi apparatus]]
-[[Category: Membrane]]
-[[Category: Mg adp befx]]
-[[Category: Molecular motor]]
-[[Category: Motor protein]]
-[[Category: Myosin]]
-[[Category: Myosin vi]]
-[[Category: Nucleotide-binding]]
-[[Category: Nucleus]]
-[[Category: Phosphorylation]]
-[[Category: Post-rigor state]]
-[[Category: Protein transport]]
-[[Category: Transport]]