Sandbox Reserved 1716: Difference between revisions
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== Introduction == | == Introduction == | ||
[[Image:VKORimage3.png|400px|right|thumb|Figure 1. Closed Conformation of VKOR due to Warfarin Binding]] | [[Image:VKORimage3.png|400px|right|thumb|Figure 1. Closed Conformation of VKOR due to Warfarin Binding]] | ||
Vitamin K Epoxide Reductase (VKOR) is an endoplasmic membrane enzyme that generates the active form of Vitamin K to support blood coagulation. The vitamin K Cycle, and the VKOR enzyme specifically are common drug targets for thromboembolic diseases. This is because, as pictured, the vitamin K cycle is the process in which blood coagulant factors II, VII, IX, and X are activated. This promotes blood clotting, which can be dangerous and cause thromboembolic diseases such as stroke, deep vein thrombosis, and/or pulmonary embolism. | |||
Vitamin K Epoxide Reductase | |||
===Location of Enzyme === | ===Location of Enzyme === | ||
== Structure == | == Structure == | ||
