Sandbox Reserved 1713: Difference between revisions
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<scene name='90/904318/Alkal1membraneinteraction/2'>Text To Be Displayed</scene>{{Template:CH462_Biochemistry_II_2022}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | <scene name='90/904318/Alkal1membraneinteraction/2'>Text To Be Displayed</scene>{{Template:CH462_Biochemistry_II_2022}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
=Anaplastic Lymphoma Kinase= | =Anaplastic Lymphoma Kinase= | ||
==Background== | |||
The anaplastic lymphoma kinase was first discovered in 1994 as a tyrosine kinase in a type of lymphoma cancer cell. ALK is a specific type of [https://link.springer.com/article/10.1186/s12943-018-0782-4 RTK] which plays a huge role in transmembrane signaling and communication within the cell. ALK is commonly expressed in the development of the nervous system. Anaplastic Lymphoma Kinase receptor is a membrane-bound tyrosine [https://pubmed.ncbi.nlm.nih.gov/32114309/ kinase]. The ALK transfers a phosphate group from [https://www.ncbi.nlm.nih.gov/books/NBK553175/ ATP] to a tyrosine residue on an enzyme which activates a signaling cascade, and ALK becomes activated when a ligand called [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789956/ ALKAL] binds to the binding surface on an extracellular domain of ALK. ALK is an integral membrane protein. Abnormal forms of ALK are closely related to the formation of several cancers. | |||
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
== Structure & Function == | == Structure & Function == | ||
