Sandbox Reserved 1713: Difference between revisions
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In order for the Anaplastic Lymphoma Kinase (ALK) to move across the membrane to bind with the second monomer, it has to undergo a conformational change. The Anaplastic Lymphoma Kinase Activating Ligand (ALKAL) binds to the binding surface on the ALK. This induces a conformational change which allows for the PXL and the GlyR domains to hinge forward. <ref>DOI: 10.1038/s41586-021-04140-8</ref> The kinase is now ready to move across the membrane and attach to the other kinase to be fully activated. | In order for the Anaplastic Lymphoma Kinase (ALK) to move across the membrane to bind with the second monomer, it has to undergo a conformational change. The Anaplastic Lymphoma Kinase Activating Ligand (ALKAL) binds to the binding surface on the ALK. This induces a conformational change which allows for the PXL and the GlyR domains to hinge forward. <ref>DOI: 10.1038/s41586-021-04140-8</ref> The kinase is now ready to move across the membrane and attach to the other kinase to be fully activated. | ||
===Movement across the membrane=== | ===Movement across the membrane=== | ||
The negatively charged phosphate groups on the cell membrane interact with the highly conserved positively charged residues on ALKAL ligand that face the membrane, which stabilizes the ligand to bind to ALK even better. | The negatively charged phosphate groups on the cell membrane interact with the highly conserved positively charged residues on ALKAL ligand that face the membrane, which stabilizes the ligand to bind to ALK even better. <ref>DOI: 10.1038/s41586-021-04140-8</ref> | ||
== Disease == | == Disease == | ||
<scene name='90/904318/Premutationresidues/2'>mutated residues</scene> | <scene name='90/904318/Premutationresidues/2'>mutated residues</scene> | ||
