Sandbox Reserved 1722: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Paola Ariza (talk | contribs) No edit summary |
Paola Ariza (talk | contribs) No edit summary |
||
| Line 15: | Line 15: | ||
=== MRGPRs === | === MRGPRs === | ||
The human itch GPCR, or Mas-related G-protein coupled receptor (MRGPR), is a Class A GPCR found in human sensory neurons and is responsible for the sensation of “itching” caused by skin irritation and diseases, insect bites, and hypersensitivity to certain drugs. There are currently four groups consisting of MRGPRX1, MRGPRX2, MRGPRX3, and MRGPRX4. In particular, MRGPRX4 is responsible for cholestatic itch while MRGPRX2 regulates degranulation and hypersensitivity itch reactions³. These two, chiefly MRGPRX2, are often targets for drugs that result in mast cell degranulation and hypersensitivity side effects. In comparison to other Class A GPCRs, MRGPRX2 binds to an even wider range of ligands, including agonists such as; | |||
Structure with <scene name='90/904327/Overview_x2_c/1'>cortistatin</scene> | Structure with <scene name='90/904327/Overview_x2_c/1'>cortistatin</scene> | ||
