Sandbox Reserved 1722: Difference between revisions
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== Clinical Relevance == | == Clinical Relevance == | ||
Many drugs have been linked to the activation of MRGPRX2 as a side effect that causes the sensation of itchiness. Among these drugs are morphine, codeine, and dextromethorphan. These drugs have a similar structure to that of (R)- ZINC-3573, introducing the idea of a similar binding mechanism. | |||
Due to mutations in key structural features of typical Class A GPCRS, MRGPRX2, it is able to bind to a variety of substrates that then mediate the signaling pathway for the sensation of itching. | |||
== References == | == References == | ||
