Sandbox Reserved 1706: Difference between revisions
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==SPRED 1== | ==SPRED 1== | ||
SPRED 1 is a protein that binds to the GAPex domain of NF1. Its function recruits the NF1 protein when bound from the cytosol to the plasma membrane. SPRED 1 will bind to the GAPex domain of NF1 in the <scene name='90/904312/Sped-1_closed/7'>closed conformation'</scene> in the cytosol to recruit NF1 to the plasma membrane. Unlike Ras, SPRED-1 does show the ability to <scene name='90/904312/Spred-1_open/1'>bind to the open conformation</scene>. When bound to the open conformation of NF1 in the cytosol, it may present a different orientation that impacts the recruitment to the plasma membrane. Further research is needed to assess the impact of the function and the changes it may present. | SPRED 1 is a protein that binds to the GAPex domain of NF1. Its function recruits the NF1 protein when bound from the cytosol to the plasma membrane. SPRED 1 will bind to the GAPex domain of NF1 in the <scene name='90/904312/Sped-1_closed/7'>closed conformation'</scene> in the cytosol to recruit NF1 to the plasma membrane. Unlike Ras, SPRED-1 does show the ability to <scene name='90/904312/Spred-1_open/1'>bind to the open conformation</scene>. When bound to the open conformation of NF1 in the cytosol, it may present a different orientation that impacts the recruitment to the plasma membrane. Further research is needed to assess the impact of the function and the changes it may present. | ||
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