Sandbox Reserved 1709: Difference between revisions

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=== Cap Domain ===  
=== Cap Domain ===  
<scene name='90/904314/Cap_Domain/1'>VKOR Cap Domain</scene>
A key part of VKOR is the function of the <scene name='90/904314/Cap_Domain/1'>VKOR Cap Domain</scene>, which is located right above the helices of VKOR towards the intracellular part of the membrane. The cap is in a helical shape and is located in close proximity to the [[Anchor]] and beta hairpin to maintain in the proper orientation. The cap domain assists with activating Vitamin K as it induces the structural change of VKOR from the open conformation to the closed conformation when the substrate binds. This initiates a domino effect through the [https://reader.elsevier.com/reader/sd/pii/S0021925820001386?token=9F8E1964241D20488CA55E035D35D9A5D650A7B3FDAD9A5579598A8DC00127539BE71CF1785B117102144AC1F41ABB6C&originRegion=us-east-1&originCreation=20220329001707/ catalytic mechanism]. The cap domain has critical interactions that stabilize the closed conformation including a <scene name='90/904314/Disulfide_bridge_stabilization/1'>Disulfide Bridge </scene> between S43 and S51, and polar interactions from D44.
Closed conformation
 
A key part of VKOR is the function of the <scene name='90/904314/Cap_Domain/1'>VKOR Cap Domain</scene>, which is located at the top of VKOR towards the intracellular part of the membrane. The cap domain assists with activating Vitamin K as it induces the structural change of VKOR from the open conformation to the closed conformation when the substrate binds. This initiates a domino effect through the [https://reader.elsevier.com/reader/sd/pii/S0021925820001386?token=9F8E1964241D20488CA55E035D35D9A5D650A7B3FDAD9A5579598A8DC00127539BE71CF1785B117102144AC1F41ABB6C&originRegion=us-east-1&originCreation=20220329001707/ catalytic mechanism]. The cap domain has critical interactions that stabilize the closed conformation including a <scene name='90/904314/Disulfide_bridge_stabilization/1'>Disulfide Bridge </scene> between S43 and S51, and polar interactions from D44.
<scene name='90/904314/Disulfide_bridge_stabilization/1'>Disulfide Bridge Stabilization</scene>
=== Anchor ===  
=== Anchor ===  
<scene name='90/904314/Anchor_domain/1'>Anchor Domain</scene>
<scene name='90/904314/Anchor_domain/1'>Anchor Domain</scene>
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