Sandbox Reserved 1705: Difference between revisions
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== Introduction == | == Introduction == | ||
Anaplastic lymphoma kinase is a receptor tyrosine kinase (RTK) that is important in regulating functions within the central nervous system <ref name="Reshetnyak">PMID:34819673</ref>. The route to | Anaplastic lymphoma kinase is a receptor tyrosine kinase (RTK) that is important in regulating functions within the central nervous system <ref name="Reshetnyak">PMID:34819673</ref>. The route to discovery of this protein's structure was rather complex, spanning almost 20 years; the kinase domain was discovered in 1994, the full protein structure in 1997, and the ligand structures in 2014. These structures were found using [https://www.chemistryworld.com/news/explainer-what-is-cryo-electron-microscopy/3008091.article cryo-electron microscopy],[https://www.britannica.com/science/nuclear-magnetic-resonance nuclear magnetic resonance], and [https://www.sciencemuseum.org.uk/objects-and-stories/chemistry/x-ray-crystallography-revealing-our-molecular-world#:~:text=X%2Dray%20crystallography%20is%20a,called%20an%20x%2Dray%20camera. X-ray crystallography]. Anaplastic lymphoma kinase is a proto-oncogene with mutations associated with various types of cancers, including non-small-cell lung cancer, anaplastic large cell lymphoma, squamous cell carcinoma, and inflammatory myofibroblastic cancer <ref name="Palmer">PMID:19459784</ref>. | ||
== General Structure == | == General Structure == | ||
