Sandbox Reserved 1706: Difference between revisions
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. The <scene name='90/904311/Closed_conformation/3'>closed conformation</scene> can exist naturally without any form of stabilization but will also fall back to the <scene name='90/904311/Open_conformation/2'>open conformation</scene>.<ref name="Bourne"> DOI:10.1038/39470</ref> <ref name="Lupton"> DOI:10.1038/s41594-021-00687-2</ref><ref name="Naschberger"> DOI:10.1038/s41586-021-04024-x</ref> | . The <scene name='90/904311/Closed_conformation/3'>closed conformation</scene> can exist naturally without any form of stabilization but will also fall back to the <scene name='90/904311/Open_conformation/2'>open conformation</scene>.<ref name="Bourne"> DOI:10.1038/39470</ref> <ref name="Lupton"> DOI:10.1038/s41594-021-00687-2</ref><ref name="Naschberger"> DOI:10.1038/s41586-021-04024-x</ref> | ||
====Zinc Stabilized==== | ====Zinc Stabilized==== | ||
The <scene name='90/904311/Closed_conformation/3'>closed conformation</scene> of Neurofibromin can be stabilized by a zinc ion to prevent the shift back to an <scene name='90/904311/Open_conformation/2'>open conformation</scene>. This binding is done between <scene name='90/904311/Zinc_binding_site/5'>Cys1032, His1558, His1576, and Zinc</scene>. Cys1032 | The <scene name='90/904311/Closed_conformation/3'>closed conformation</scene> of Neurofibromin can be stabilized by a zinc ion to prevent the shift back to an <scene name='90/904311/Open_conformation/2'>open conformation</scene>. This binding is done between <scene name='90/904311/Zinc_binding_site/5'>Cys1032, His1558, His1576, and Zinc</scene>. Cys1032 is within the N-HEAT domain and both His1558 and His1576 are within the GAPex-subdomain. When zinc stabilizes Neurofibromin, it will stay in the <scene name='90/904311/Closed_conformation/3'>closed conformation</scene> and continue to inhibit the binding of RAS.<ref name="Bourne"> DOI:10.1038/39470</ref><ref name="Lupton"> DOI:10.1038/s41594-021-00687-2</ref><ref name="Naschberger"> DOI:10.1038/s41586-021-04024-x</ref> | ||
===Open conformation=== | ===Open conformation=== | ||
In the open state, one of the protomers remains in the closed confirmation inaccessible to Ras, while the other protomer is conformationally changed into the open form with Ras bound. | In the open state, one of the protomers remains in the closed confirmation inaccessible to Ras, while the other protomer is conformationally changed into the open form with Ras bound. | ||
