1gqf: Difference between revisions

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[[Image:1gqf.gif|left|200px]]
{{Seed}}
[[Image:1gqf.png|left|200px]]


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{{STRUCTURE_1gqf|  PDB=1gqf  |  SCENE=  }}  
{{STRUCTURE_1gqf|  PDB=1gqf  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HUMAN PROCASPASE-7'''
===CRYSTAL STRUCTURE OF HUMAN PROCASPASE-7===




==Overview==
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Caspases form a family of proteinases required for the initiation and execution phases of apoptosis. Distinct proapoptotic stimuli lead to activation of the initiator caspases-8 and -9, which in turn activate the common executioner caspases-3 and -7 by proteolytic cleavage. Whereas crystal structures of several active caspases have been reported, no three-dimensional structure of an uncleaved caspase zymogen is available so far. We have determined the 2.9-A crystal structure of recombinant human C285A procaspase-7 and have elucidated the activation mechanism of caspases. The overall fold of the homodimeric procaspase-7 resembles that of the active tetrameric caspase-7. Each monomer is organized in two structured subdomains connected by partially flexible linkers, which asymmetrically occupy and block the central cavity, a typical feature of active caspases. This blockage is incompatible with a functional substrate binding site/active site. After proteolytic cleavage within the flexible linkers, the newly formed chain termini leave the cavity and fold outward to form stable structures. These conformational changes are associated with the formation of an intact active-site cleft. Therefore, this mechanism represents a formerly unknown type of proteinase zymogen activation.
The line below this paragraph, {{ABSTRACT_PUBMED_11752425}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11752425 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11752425}}


==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Zymogen]]
[[Category: Zymogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:53:29 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:53:49 2008''

Revision as of 02:53, 1 July 2008

File:1gqf.png

Template:STRUCTURE 1gqf

CRYSTAL STRUCTURE OF HUMAN PROCASPASE-7

Template:ABSTRACT PUBMED 11752425

About this Structure

1GQF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the activation of human procaspase-7., Riedl SJ, Fuentes-Prior P, Renatus M, Kairies N, Krapp S, Huber R, Salvesen GS, Bode W, Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14790-5. PMID:11752425

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