1gql: Difference between revisions

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[[Image:1gql.gif|left|200px]]
{{Seed}}
[[Image:1gql.png|left|200px]]


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{{STRUCTURE_1gql|  PDB=1gql  |  SCENE=  }}  
{{STRUCTURE_1gql|  PDB=1gql  |  SCENE=  }}  


'''STRUCTURE OF PSEUDOMONAS CELLULOSA ALPHA-D-GLUCURONIDASE COMPLEXED WITH GLUCURONIC ACID AND XYLOTRIOSE'''
===STRUCTURE OF PSEUDOMONAS CELLULOSA ALPHA-D-GLUCURONIDASE COMPLEXED WITH GLUCURONIC ACID AND XYLOTRIOSE===




==Overview==
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Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans. The structure of the alpha-glucuronidase, GlcA67A, from Pseudomonas cellulosa reveals three domains, the central of which is a (beta/alpha)(8) barrel housing the catalytic apparatus. Complexes of the enzyme with the individual reaction products, either xylobiose or glucuronic acid, and the ternary complex of both glucuronic acid and xylotriose reveal a "blind" pocket which selects for short decorated xylooligosaccharides substituted with the uronic acid at their nonreducing end, consistent with kinetic data. The catalytic center reveals a constellation of carboxylates; Glu292 is poised to provide protonic assistance to leaving group departure with Glu393 and Asp365 both appropriately positioned to provide base-catalyzed assistance for inverting nucleophilic attack by water.
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{{ABSTRACT_PUBMED_11937059}}


==About this Structure==
==About this Structure==
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[[Category: Structure]]
[[Category: Structure]]
[[Category: Xylotriose]]
[[Category: Xylotriose]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:53:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:54:22 2008''

Revision as of 02:54, 1 July 2008

File:1gql.png

Template:STRUCTURE 1gql

STRUCTURE OF PSEUDOMONAS CELLULOSA ALPHA-D-GLUCURONIDASE COMPLEXED WITH GLUCURONIC ACID AND XYLOTRIOSE

Template:ABSTRACT PUBMED 11937059

About this Structure

1GQL is a Single protein structure of sequence from Cellvibrio japonicus. Full crystallographic information is available from OCA.

Reference

The structural basis for catalysis and specificity of the Pseudomonas cellulosa alpha-glucuronidase, GlcA67A., Nurizzo D, Nagy T, Gilbert HJ, Davies GJ, Structure. 2002 Apr;10(4):547-56. PMID:11937059

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