1gqv: Difference between revisions

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[[Image:1gqv.jpg|left|200px]]
{{Seed}}
[[Image:1gqv.png|left|200px]]


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{{STRUCTURE_1gqv|  PDB=1gqv  |  SCENE=  }}  
{{STRUCTURE_1gqv|  PDB=1gqv  |  SCENE=  }}  


'''ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN'''
===ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN===




==Overview==
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Human eosinophil-derived neurotoxin (EDN) is a small, basic protein that belongs to the ribonuclease A superfamily. EDN displays antiviral activity and causes the neurotoxic Gordon phenomenon when injected into rabbits. Although EDN and ribonuclease A have appreciable structural similarity and a conserved catalytic triad, their peripheral substrate-binding sites are not conserved. The crystal structure of recombinant EDN (rEDN) has been determined at 0.98 A resolution from data collected at a low temperature (100 K). We have refined the crystallographic model of the structure using anisotropic displacement parameters to a conventional R-factor of 0.116. This represents the highest resolution structure of rEDN determined to date and is only the second ribonuclease structure to be determined at a resolution greater than 1.0 A. The structure provides a detailed picture of the conformational freedom at the various subsites of rEDN, and the water structure accounts for more than 50% of the total solvent content of the unit cell. This information will be crucial for the design of tight-binding inhibitors to restrain the ribonucleolytic activity of rEDN.
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{{ABSTRACT_PUBMED_11876642}}


==About this Structure==
==About this Structure==
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[[Category: Rnase us]]
[[Category: Rnase us]]
[[Category: Rnase-2]]
[[Category: Rnase-2]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:54:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:55:34 2008''

Revision as of 02:55, 1 July 2008

File:1gqv.png

Template:STRUCTURE 1gqv

ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN

Template:ABSTRACT PUBMED 11876642

About this Structure

1GQV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Atomic resolution (0.98 A) structure of eosinophil-derived neurotoxin., Swaminathan GJ, Holloway DE, Veluraja K, Acharya KR, Biochemistry. 2002 Mar 12;41(10):3341-52. PMID:11876642

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