4bgq: Difference between revisions

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<StructureSection load='4bgq' size='340' side='right'caption='[[4bgq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4bgq' size='340' side='right'caption='[[4bgq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4bgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BGQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4bgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BGQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=38R:[4-({4-[(3-CYCLOPENTYL-1H-PYRAZOL-5-YL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETONITRILE'>38R</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=38R:[4-({4-[(3-CYCLOPENTYL-1H-PYRAZOL-5-YL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETONITRILE'>38R</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bgq OCA], [https://pdbe.org/4bgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bgq RCSB], [https://www.ebi.ac.uk/pdbsum/4bgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bgq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bgq OCA], [https://pdbe.org/4bgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bgq RCSB], [https://www.ebi.ac.uk/pdbsum/4bgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bgq ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/CDKL5_HUMAN CDKL5_HUMAN]] Note=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15).  Epileptic encephalopathy, early infantile, 2 (EIEE2) [MIM:[https://omim.org/entry/300672 300672]]: A severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients with epileptic encephalopathy early infantile type 2 manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15917271</ref> <ref>PMID:16935860</ref> <ref>PMID:12736870</ref> <ref>PMID:15492925</ref> <ref>PMID:15499549</ref> <ref>PMID:15689447</ref> <ref>PMID:16015284</ref> <ref>PMID:16611748</ref> <ref>PMID:18790821</ref> <ref>PMID:17993579</ref> <ref>PMID:18809835</ref> <ref>PMID:19253388</ref> <ref>PMID:19241098</ref>
[https://www.uniprot.org/uniprot/CDKL5_HUMAN CDKL5_HUMAN] Note=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15).  Epileptic encephalopathy, early infantile, 2 (EIEE2) [MIM:[https://omim.org/entry/300672 300672]: A severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients with epileptic encephalopathy early infantile type 2 manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:15917271</ref> <ref>PMID:16935860</ref> <ref>PMID:12736870</ref> <ref>PMID:15492925</ref> <ref>PMID:15499549</ref> <ref>PMID:15689447</ref> <ref>PMID:16015284</ref> <ref>PMID:16611748</ref> <ref>PMID:18790821</ref> <ref>PMID:17993579</ref> <ref>PMID:18809835</ref> <ref>PMID:19253388</ref> <ref>PMID:19241098</ref>  
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CDKL5_HUMAN CDKL5_HUMAN]] Mediates phosphorylation of MECP2.<ref>PMID:15917271</ref> <ref>PMID:16935860</ref>
[https://www.uniprot.org/uniprot/CDKL5_HUMAN CDKL5_HUMAN] Mediates phosphorylation of MECP2.<ref>PMID:15917271</ref> <ref>PMID:16935860</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cyclin-dependent kinase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Bullock, A]]
[[Category: Bullock A]]
[[Category: Canning, P]]
[[Category: Canning P]]
[[Category: Delft, F von]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: Goubin S]]
[[Category: Goubin, S]]
[[Category: Krojer T]]
[[Category: Krojer, T]]
[[Category: Mahajan P]]
[[Category: Mahajan, P]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W]]
[[Category: Vollmar M]]
[[Category: Vollmar, M]]
[[Category: Von Delft F]]
[[Category: Kinase]]
[[Category: Phospho-mimetic]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4bgq"