Sandbox Reserved 1709: Difference between revisions

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== Disease and Treatment ==

=== Afflictions ===

Since activated Vitamin K plays a crucial role in blood coagulation ~~in the body~~, ~~any~~ defects in the function and enzymatic activity of VKOR may ~~have detrimental effects~~ on Vitamin K's ability to promote ~~important~~ blood clotting. ~~Ultimately, mutations~~ in VKOR ~~may lead to increased~~ susceptibility to vascular diseases, such as a stroke [https://doi.org/10.1161/CIRCULATIONAHA.105.580167]. Vitamin K ~~has~~ also ~~been shown to have an~~ important ~~role~~ in maintaining bone health~~, so~~ inactivity of VKOR ~~could also be~~ linked to decreased bone density and osteoporosis [https://doi.org/10.7759/cureus.10816].

Since activated Vitamin K plays a crucial role in blood coagulation, defects in the function and enzymatic activity of VKOR may detrimentally effect on Vitamin K's ability to promote blood clotting. Mutations in VKOR also increase susceptibility to vascular diseases, such as a stroke [https://doi.org/10.1161/CIRCULATIONAHA.105.580167]. Vitamin K is also important in maintaining bone health with inactivity of VKOR linked to decreased bone density and osteoporosis [https://doi.org/10.7759/cureus.10816].

=== Inhibition ===

The most inexpensive and common way to treat blood clotting is through the VKOR inhibitor, <scene name='90/906893/Vkor_with_warfarin_bound/2'>Warfarin</scene>. [https://en.wikipedia.org/wiki/Warfarin Warfarin] is able to do so by outcompeting KO, such that Vitamin K cannot be activated to promote coagulation in the blood. Warfarin will enter the binding pocket of VKOR, creating strong hydrogen bonds with the active site. Warfarin resistance may also occur due to mutations of VKOR, decreasing the effective anticoagulation some drugs may be attempting to promote. The degree of resistance is important to determine so that warfarin may be an effective anticoagulant without being detrimentally effective in blood flow.

Sandbox Reserved 1709: Difference between revisions

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@@ Line 34: / Line 34: @@
 == Disease and Treatment ==
 === Afflictions ===
-Since activated Vitamin K plays a crucial role in blood coagulation in the body, any defects in the function and enzymatic activity of VKOR may have detrimental effects on Vitamin K's ability to promote important blood clotting. Ultimately, mutations in VKOR may lead to increased susceptibility to vascular diseases, such as a stroke [https://doi.org/10.1161/CIRCULATIONAHA.105.580167]. Vitamin K has also been shown to have an important role in maintaining bone health, so inactivity of VKOR could also be linked to decreased bone density and osteoporosis [https://doi.org/10.7759/cureus.10816].
+Since activated Vitamin K plays a crucial role in blood coagulation, defects in the function and enzymatic activity of VKOR may detrimentally effect on Vitamin K's ability to promote blood clotting. Mutations in VKOR also increase susceptibility to vascular diseases, such as a stroke [https://doi.org/10.1161/CIRCULATIONAHA.105.580167]. Vitamin K is also important in maintaining bone health with inactivity of VKOR linked to decreased bone density and osteoporosis [https://doi.org/10.7759/cureus.10816].
 === Inhibition ===
 The most inexpensive and common way to treat blood clotting is through the VKOR inhibitor, <scene name='90/906893/Vkor_with_warfarin_bound/2'>Warfarin</scene>. [https://en.wikipedia.org/wiki/Warfarin Warfarin] is able to do so by outcompeting KO, such that Vitamin K cannot be activated to promote coagulation in the blood. Warfarin will enter the binding pocket of VKOR, creating strong hydrogen bonds with the active site. Warfarin resistance may also occur due to mutations of VKOR, decreasing the effective anticoagulation some drugs may be attempting to promote. The degree of resistance is important to determine so that warfarin may be an effective anticoagulant without being detrimentally effective in blood flow.