Sandbox Reserved 1716: Difference between revisions

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~~[[Image:VKORimage3.png|250px|right|thumb|Figure 1. Closed Conformation of VKOR due to Warfarin Binding]]~~

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== Introduction ==

[[Image:NewVitaminKCycle.PNG|200px|right|thumb|'''Figure 2. Overview of Vitamin K Cycle''': The cycle begins with Vitamin K Quinone. Vitamin K Quinone is reduced by enzyme Quinone Reductase. This leaves Vitamin K Hydroquinone which can either lead to Gamma Carboxylase activity that will activate Blood Coagulation Factors II, VII, IX, and X. After this, Vitamin K Epoxide is left over. Vitamin K Epoxide is reduced by the enzyme Vitamin K Epoxide Reductase to reform Vitamin K Quinone. ]]

[[Image:NewVitaminKCycle.PNG|200px|right|thumb|'''Figure 2. Overview of Vitamin K Cycle''': The cycle begins with Vitamin K Quinone [https://en.wikipedia.org/wiki/Vitamin_K]. Vitamin K Quinone is reduced by enzyme Quinone Reductase. This leaves Vitamin K Hydroquinone which can either lead to Gamma Carboxylase activity that will activate Blood Coagulation Factors II, VII, IX, and X. After this, Vitamin K Epoxide is left over. Vitamin K Epoxide is reduced by the enzyme Vitamin K Epoxide Reductase to reform Vitamin K Quinone. ]]

'''Vitamin K Epoxide Reductase''' <scene name='90/904321/Closedconformation/2'>Spinning VKOR</scene>

[https://en.wikipedia.org/wiki/Vitamin_K_epoxide_reductase VKOR WIKI](VKOR) is an endoplasmic membrane enzyme that generates the active form of Vitamin K to support blood coagulation. VKOR homologs are integral membrane thiol oxidoreductases due to the function of VKOR being dependent on thiol residues and disulfide bonding. The Vitamin K Cycle and the VKOR enzyme specifically are common drug targets for thromboembolic diseases. This is because, as pictured, the vitamin K cycle is required to activate blood coagulant factors II, VII, IX, and X. Coagulant factor activation promotes blood clotting, which in high amounts can be dangerous and cause thromboembolic diseases such as stroke, deep vein thrombosis, and/or pulmonary embolism. Vitamin K Epoxide Reductase is found and primarily synthesized in the liver. It is embedded in the membrane known as the endoplasmic reticulum.

Sandbox Reserved 1716: Difference between revisions

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 <StructureSection load='' size='350' side='right' caption='Structure of Closed Vitamin K Epoxide Reductase (PDB entry [[6wv3]])' scene='90/904321/Closedconformation/2'>
-[[Image:VKORimage3.png|250px|right|thumb|Figure 1. Closed Conformation of VKOR due to Warfarin Binding]]
@@ Line 10: / Line 10: @@
 == Introduction ==
-[[Image:NewVitaminKCycle.PNG|200px|right|thumb|'''Figure 2. Overview of Vitamin K Cycle''': The cycle begins with Vitamin K Quinone. Vitamin K Quinone is reduced by enzyme Quinone Reductase. This leaves Vitamin K Hydroquinone which can either lead to Gamma Carboxylase activity that will activate Blood Coagulation Factors II, VII, IX, and X. After this, Vitamin K Epoxide is left over. Vitamin K Epoxide is reduced by the enzyme Vitamin K Epoxide Reductase to reform Vitamin K Quinone. ]]
+[[Image:NewVitaminKCycle.PNG|200px|right|thumb|'''Figure 2. Overview of Vitamin K Cycle''': The cycle begins with Vitamin K Quinone [https://en.wikipedia.org/wiki/Vitamin_K]. Vitamin K Quinone is reduced by enzyme Quinone Reductase. This leaves Vitamin K Hydroquinone which can either lead to Gamma Carboxylase activity that will activate Blood Coagulation Factors II, VII, IX, and X. After this, Vitamin K Epoxide is left over. Vitamin K Epoxide is reduced by the enzyme Vitamin K Epoxide Reductase to reform Vitamin K Quinone. ]]
 '''Vitamin K Epoxide Reductase''' <scene name='90/904321/Closedconformation/2'>Spinning VKOR</scene>
 [https://en.wikipedia.org/wiki/Vitamin_K_epoxide_reductase VKOR WIKI](VKOR) is an endoplasmic membrane enzyme that generates the active form of Vitamin K to support blood coagulation. VKOR homologs are integral membrane thiol oxidoreductases due to the function of VKOR being dependent on thiol residues and disulfide bonding. The Vitamin K Cycle and the VKOR enzyme specifically are common drug targets for thromboembolic diseases. This is because, as pictured, the vitamin K cycle is required to activate blood coagulant factors II, VII, IX, and X. Coagulant factor activation promotes blood clotting, which in high amounts can be dangerous and cause thromboembolic diseases such as stroke, deep vein thrombosis, and/or pulmonary embolism. Vitamin K Epoxide Reductase is found and primarily synthesized in the liver. It is embedded in the membrane known as the endoplasmic reticulum.