7u4k: Difference between revisions
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==Crystal structure of human GPX4-U46C-R152H in complex with ML162== | |||
<StructureSection load='7u4k' size='340' side='right'caption='[[7u4k]], [[Resolution|resolution]] 1.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7u4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U4K FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=L9C:2-chloro-N-(3-chloro-4-methoxyphenyl)-N-[(1R)-2-oxo-2-[(2-phenylethyl)amino]-1-(thiophen-2-yl)ethyl]acetamide'>L9C</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u4k OCA], [https://pdbe.org/7u4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u4k RCSB], [https://www.ebi.ac.uk/pdbsum/7u4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u4k ProSAT]</span></td></tr> | ||
[[Category: Forouhar | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Forouhar F]] | |||
[[Category: Lin AJ]] | |||
[[Category: Liu H]] | |||
[[Category: Soni RK]] | |||
[[Category: Stockwell BR]] | |||
[[Category: Wang Q]] | |||
[[Category: Xia X]] | |||
Revision as of 08:12, 7 December 2022
Crystal structure of human GPX4-U46C-R152H in complex with ML162
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