2wap: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 3: Line 3:
<StructureSection load='2wap' size='340' side='right'caption='[[2wap]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='2wap' size='340' side='right'caption='[[2wap]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wap]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WAP FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wap]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WAP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PIX:4-(3-{[5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}BENZYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PIX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mt5|1mt5]], [[2vya|2vya]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PIX:4-(3-{[5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}BENZYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PIX</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Amidase Amidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wap OCA], [https://pdbe.org/2wap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wap RCSB], [https://www.ebi.ac.uk/pdbsum/2wap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wap ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wap OCA], [https://pdbe.org/2wap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wap RCSB], [https://www.ebi.ac.uk/pdbsum/2wap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wap ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).  
[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 37: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Amidase]]
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kamtekar, S]]
[[Category: Rattus norvegicus]]
[[Category: Mileni, M]]
[[Category: Kamtekar S]]
[[Category: Stevens, R C]]
[[Category: Mileni M]]
[[Category: Acyl- enzyme]]
[[Category: Stevens RC]]
[[Category: Drug]]
[[Category: Endoplasmic reticulum]]
[[Category: Faah]]
[[Category: Fatty acid amide hydrolase]]
[[Category: Golgi apparatus]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: Membrane]]
[[Category: Phosphoprotein]]
[[Category: Transmembrane]]
[[Category: Urea inhibitor]]
Retrieved from "https://proteopedia.org/2wap"